喹啉 N-氧化物的钯催化氧化 C8 选择性 C-H 均偶联反应的实验与机理分析
Experimental and mechanistic analysis of the palladium-catalyzed oxidative C8-selective C-H homocoupling of quinoline N-oxides.
作者信息
Stephens David E, Lakey-Beitia Johant, Chavez Gabriel, Ilie Carla, Arman Hadi D, Larionov Oleg V
机构信息
Department of Chemistry, University of Texas at San Antonio, San Antonio, TX 78249, USA.
出版信息
Chem Commun (Camb). 2015 Jun 11;51(46):9507-10. doi: 10.1039/c5cc02227d.
Abstract
A novel site-selective palladium-catalyzed oxidative C8-H homocoupling reaction of quinoline N-oxides has been developed. The reaction affords substituted 8,8'-biquinolyl N,N'-dioxides that can be readily converted to a variety of functionalized 8,8'-biquinolyls. Mechanistic studies point to the crucial role of the oxidant and a non-innocent behavior of acetic acid as a solvent.
摘要
已开发出一种新型的喹啉 N-氧化物的位点选择性钯催化氧化 C8-H 同偶联反应。该反应可得到取代的 8,8'-联喹啉 N,N'-二氧化物，其可容易地转化为各种功能化的 8,8'-联喹啉。机理研究表明氧化剂起着关键作用，且乙酸作为溶剂具有非无害行为。
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