维生素D缺乏与危重病
Vitamin D Deficiency and Critical Illness.
作者信息
Prasad Shailender, Raj Dinesh, Warsi Sumbul, Chowdhary Sona
机构信息
Department of Pediatrics, Holy Family Hospital, New Delhi, 110025, India.
出版信息
Indian J Pediatr. 2015 Nov;82(11):991-5. doi: 10.1007/s12098-015-1778-3. Epub 2015 May 14.
OBJECTIVE
To determine the prevalence of vitamin D deficiency in critically ill children and assess its association with severity of illness and other outcomes associated with critical illness.
METHODS
Eighty children aged 2 mo to 12 y, admitted with medical conditions to the pediatric intensive care unit of a tertiary care hospital were enrolled in this prospective observational study. Vitamin D levels were obtained during the first hour of stay. Severity score was assessed using the Pediatric Risk of Mortality III (PRISM III) within first 12 h of admission.
RESULTS
Vitamin D deficiency {25-hydroxy vitamin D [25(OH)D] levels < 20 ng/ml} was observed in 67 (83.8%) children. Vitamin D deficient children had significantly higher PRISM III score compared to vitamin D sufficient children [10 (IQR:5-15) vs. 6 (IQR:3-7); p 0.0099]. 25(OH)D levels had a significant negative correlation with PRISM III score (ρ -0.3747; p 0.0006).
CONCLUSIONS
Vitamin D appears to be of utmost importance in critically ill children.
目的
确定危重症儿童维生素D缺乏症的患病率，并评估其与疾病严重程度以及危重症相关的其他结局之间的关联。
方法
本前瞻性观察性研究纳入了80名年龄在2个月至12岁之间、因内科疾病入住一家三级护理医院儿科重症监护病房的儿童。在入住后的第一小时内检测维生素D水平。在入院后的前12小时内使用儿童死亡风险Ⅲ（PRISMⅢ）评估疾病严重程度评分。
结果
67名（83.8%）儿童存在维生素D缺乏症{25-羟维生素D[25(OH)D]水平<20 ng/ml}。与维生素D充足的儿童相比，维生素D缺乏的儿童PRISMⅢ评分显著更高[10（四分位间距：5-15）对6（四分位间距：3-7）；p=0.0099]。25(OH)D水平与PRISMⅢ评分呈显著负相关（ρ=-0.3747；p=0.0006）。
结论
维生素D在危重症儿童中似乎至关重要。
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