Landry S L, Kaiser D L, Wenzel R P
Department of Internal Medicine, University of Virginia Medical Center, Charlottesville.
Am J Infect Control. 1989 Dec;17(6):323-9. doi: 10.1016/0196-6553(89)90001-1.
A retrospective cohort study of 97 patients identified by prospective hospital-wide surveillance was conducted to determine the length of hospital stay and mortality attributed to hospital-acquired enterococcal bacteremia. The mean duration of hospitalization for cases was 83 days compared with 44 days for matched controls (p = 0.0001). The mortality rate during the study period was 43% among cases and 12% in matched controls (p less than 0.001). Thus the mortality rate attributable to enterococcal bacteremia was 31% and the risk ratio was 4.75. Stepwise discriminant function analysis indicated that the use of vascular catheters and renal dialysis and the presence of immune deficiency were predictors of fatal outcome in cases. Enterococcal bacteremia has become a prominent nosocomial pathogen and is associated with mortality rates well above those expected from the underlying disease.
一项对97例通过前瞻性全院监测确定的患者进行的回顾性队列研究，旨在确定医院获得性肠球菌菌血症所致的住院时间和死亡率。病例组的平均住院时间为83天，而匹配对照组为44天（p = 0.0001）。研究期间，病例组的死亡率为43%，匹配对照组为12%（p<0.001）。因此，肠球菌菌血症所致的死亡率为31%，风险比为4.75。逐步判别函数分析表明，使用血管导管和进行肾透析以及存在免疫缺陷是病例组死亡结局的预测因素。肠球菌菌血症已成为一种突出的医院病原体，其死亡率远高于基础疾病预期的死亡率。
