Babalis D C, Boutos G N, Iliodromitis E K, Trovas A K, Vorides E M
2nd Cardiology Department, Evangelismos Hospital, Athens, Greece.
Angiology. 1989 Dec;40(12):1040-7. doi: 10.1177/000331978904001204.
Repeated precordial ECG mapping (42 leads) and CK-MB serum measurements were done in 40 patients with anterior and/or anterolateral acute myocardial infarction. Twenty patients serving as controls, were treated with routine anticoagulant therapy. In 20 patients (the s group), randomly selected, a short-term IV infusion of 1,500,000 IU streptokinase was administered and followed by the same anticoagulant treatment as in controls. Ten subjects from each group underwent coronary arteriography one month later. From the analysis of ECG mapping the number of leads (N) and the sum of measurements (sigma) for each parameter were calculated. Before treatment there were no significant differences for all measured parameters between the two groups of patients. Seven days later, ST elevations were statistically different for NST and sigma ST with lower values for the s group. Higher values for NR and sigma R were also noted in this group. No statistically significant difference was found for NQ and sigma Q. CK-MB curve showed an earlier peak in the s group than in the control group. Five patients from the s group showed a patency of the infarct-related vessel. In conclusion, the results of this study show that patients receiving s have a significant benefit with ECG improvement. On the other hand, the CK-MB curve indicates an eventual recanalization to a certain degree in the obstructed coronary artery, which is the final goal.
对40例急性前壁和/或前侧壁心肌梗死患者进行了重复的心前区心电图标测（42导联）和血清肌酸激酶同工酶（CK-MB）测定。20例患者作为对照组，接受常规抗凝治疗。随机选取20例患者（s组），静脉短期输注150万国际单位链激酶，随后给予与对照组相同的抗凝治疗。每组10名受试者在1个月后接受冠状动脉造影。通过对心电图标测的分析，计算每个参数的导联数（N）和测量值总和（σ）。治疗前，两组患者所有测量参数均无显著差异。7天后，s组的NST和σST的ST段抬高在统计学上有差异，s组的值较低。该组的NR和σR值也较高。NQ和σQ未发现统计学上的显著差异。CK-MB曲线显示s组比对照组出现峰值更早。s组有5例梗死相关血管通畅。总之，本研究结果表明，接受s治疗的患者在心电图改善方面有显著益处。另一方面，CK-MB曲线表明阻塞的冠状动脉最终在一定程度上实现了再通，这是最终目标。
