Karlsson-Borgå A, Jonsson P, Rolfsen W
Pharmacia Diagnostics AB, Uppsala, Sweden.
Ann Allergy. 1989 Dec;63(6 Pt 1):521-6.
A panel of 55 sera from patients with suspected mold allergy from two different geographic areas, A and B, was investigated for specific IgE antibodies to 16 individual molds using Phadebas RAST technique. The molds investigated were Alternaria, Cladosporium, Aspergillus, Penicillium, Mucor, and Candida from the former RAST panel and ten additional new mold genera. The RAST screening revealed that 73% of patients had specific IgE antibodies to at least one of the 16 molds. Eighteen percent were negative to the six molds of the previous RAST panel but had specific IgE antibodies to at least one of the ten new molds. The highest frequency of IgE antibodies in the A group could be assigned to Cladosporium, followed by Botrytis and Helminthosporium. In group B, sensitivity to Botrytis and Phoma showed the highest frequencies. This study revealed that the relative importance of mold genera may vary greatly between patient groups from different geographic areas. Some of the species of the expanded RAST panel seem to be at least as important as Alternaria and Cladosporium. Multiple sensitivities seem to be caused by sensitization by many mold species rather than by cross-reactivity.
使用Phadebas RAST技术，对来自两个不同地理区域A和B的55份疑似霉菌过敏患者的血清样本进行检测，以分析针对16种不同霉菌的特异性IgE抗体。所检测的霉菌包括来自之前RAST检测组的链格孢属、枝孢属、曲霉属、青霉属、毛霉属和念珠菌属，以及另外10个新增的霉菌属。RAST检测显示，73%的患者对16种霉菌中的至少一种具有特异性IgE抗体。18%的患者对之前RAST检测组中的6种霉菌呈阴性，但对10种新霉菌中的至少一种具有特异性IgE抗体。A组中IgE抗体出现频率最高的是枝孢属，其次是葡萄孢属和长蠕孢属。在B组中，对葡萄孢属和茎点霉属的敏感性出现频率最高。该研究表明，不同地理区域的患者组中，霉菌属的相对重要性可能有很大差异。扩展后的RAST检测组中的一些菌种似乎与链格孢属和枝孢属至少具有同等重要性。多种敏感性似乎是由多种霉菌菌种致敏引起的，而非交叉反应所致。
