Sato Nobuyuki, Sasaki Rie, Imahashi Marina, Ito Eisuke, Saito Kumiko, Kubota Haruyo, Talib Ahmed Karim, Sakamoto Naka, Akasaka Kazumi, Saijo Yasuaki, Kawamura Yuichiro, Fujii Satoshi, Hasebe Naoyuki
Department of Cardiology, Asahikawa Medical University.
Department of Medical Laboratory and Blood Center, Asahikawa Medical University Hospital.
Magnes Res. 2015 Jan-Mar;28(1):1-13. doi: 10.1684/mrh.2015.0379.
Intravenous administration of magnesium (Mg(2+)) is effective for polymorphic ventricular tachycardia via homogenization of transmural ventricular repolarization. Mg(2+) likely plays some role in the heterogeneity of repolarization in J wave syndromes.
To investigate the relationship between the repolarization parameters and serum Mg(2+), potassium (K(+)), and calcium (Ca(2+)) levels in J wave syndromes.
Thirteen J-wave syndrome patients (Brugada and early repolarization [ER] syndromes), with documented episodes of ventricular fibrillation (VF), and 13 ER pattern (ERP) or Brugada type ECG patients were enrolled (25 males, mean age 48 ± 15 years). The 12-lead ECG-derived parameters including the QT, QT dispersion (QTd), Tpeak-Tend (Tp-e) interval, Tp-e dispersion (Tp-ed), Tp-e/QT ratio, and activation recovery interval (ARI) dispersion were calculated; the correlations between these parameters and electrolytes including Mg(2+), K(+), and Ca(2+) were analyzed.
Although there was no association between serum K(+) or Ca(2+) and QTd, there was a strong negative correlation between serum Mg(2+) and QTd in J wave syndrome patients with a history of VF (r = -0.715, p = 0.006). Also, there was a tendency for a negative correlation between Mg(2+) and Tp-ed or ARI dispersion in J wave syndrome patients with a history of VF (r = -0.513, p = 0.072 and r = -0.53, p = 0.063, respectively). On the other hand, in 13 patients with a Brugada type ECG or ERP, no correlation was observed between serum Mg(2+) and the QTd, Tp-ed or ARI dispersion.
Serum Mg(2+) may play an important role in the cardiac repolarization process in J wave syndromes.
静脉注射镁离子（Mg(2+)）可通过使心室跨壁复极均匀化来有效治疗多形性室性心动过速。Mg(2+)可能在J波综合征的复极异质性中发挥一定作用。
研究J波综合征患者复极参数与血清Mg(2+)、钾离子（K(+)）和钙离子（Ca(2+)）水平之间的关系。
纳入13例有记录的室颤（VF）发作的J波综合征患者（Brugada综合征和早期复极[ER]综合征）以及13例ER图形（ERP）或Brugada型心电图患者（25例男性，平均年龄48±15岁）。计算12导联心电图得出的参数，包括QT、QT离散度（QTd）、T峰-T末（Tp-e）间期、Tp-e离散度（Tp-ed）、Tp-e/QT比值以及激活恢复间期（ARI）离散度；分析这些参数与包括Mg(2+)、K(+)和Ca(2+)在内的电解质之间的相关性。
虽然血清K(+)或Ca(2+)与QTd之间无关联，但有VF病史的J波综合征患者血清Mg(2+)与QTd之间存在强负相关（r = -0.715，p = 0.006）。此外，有VF病史的J波综合征患者中，Mg(2+)与Tp-ed或ARI离散度之间也有负相关趋势（分别为r = -0.513，p = 0.072和r = -0.53，p = 0.063）。另一方面，在13例Brugada型心电图或ERP患者中，未观察到血清Mg(2+)与QTd、Tp-ed或ARI离散度之间存在相关性。
血清Mg(2+)可能在J波综合征的心脏复极过程中起重要作用。
