精子特异性乳酸脱氢酶LDHC基因在人类11号染色体上的区域定位。

Regional localization of the sperm-specific lactate dehydrogenase, LDHC, gene on human chromosome 11.

作者信息

Edwards Y, West L, Van Heyningen V, Cowell J, Goldberg E

机构信息

MRC Human Biochemical Genetics Unit, Galton Laboratory, University College London.

出版信息

Ann Hum Genet. 1989 Jul;53(3):215-9. doi: 10.1111/j.1469-1809.1989.tb01787.x.

DOI:10.1111/j.1469-1809.1989.tb01787.x

PMID:2596827

Abstract

A cDNA clone complementary to the mRNA encoding the sperm-specific lactate dehydrogenase, LDHC, has been used to map the LDHC locus to the short arm of human chromosome 11. In situ hybridization data and analysis of mouse/human somatic cell hybrids carrying deletions of human chromosome 11 suggest that the gene is localized at p15.3-p15.5 close to the LDHA gene.

摘要

一个与编码精子特异性乳酸脱氢酶（LDHC）的mRNA互补的cDNA克隆，已被用于将LDHC基因座定位到人类11号染色体的短臂上。原位杂交数据以及对携带人类11号染色体缺失的小鼠/人类体细胞杂种的分析表明，该基因定位于靠近LDHA基因的p15.3 - p15.5处。