Çakır Esra D P, Sağlam Halil, Eren Erdal, Özgür Taner, Tarım Ömer F
J Pediatr Endocrinol Metab. 2015 Nov 1;28(11-12):1219-26. doi: 10.1515/jpem-2014-0007.
The objective of the study was to evaluate the pubertal development and linear growth of Turner Syndrome (TS) girls regularly monitored in our department.
The data of 13 patients with TS were evaluated retrospectively. Left hand radiograms were evaluated by three different pediatric endocrinologists to determine bone ages.
Six (46.2%) of the TS girls were treated with oral estrogens, while 7 (53.8%) were treated with transdermal estrogen. The ratios of chronological age (CA) difference to bone age (BA) difference (ΔCA/ΔBA) in two groups of patients treated with estrogen were compared at the time of the last control. The ΔCA/ΔBA ratio in the transdermal estrogen-treated group was significantly higher (p=0.005). These results suggest slower BA progression in the TS girls treated with transdermal estrogen.
BA advancement is less significant with transdermal estrogen, which is associated with adequate breast development.
本研究的目的是评估在我们科室定期监测的特纳综合征（TS）女孩的青春期发育和线性生长情况。
对13例TS患者的数据进行回顾性评估。由三位不同的儿科内分泌学家评估左手X线片以确定骨龄。
6例（46.2%）TS女孩接受口服雌激素治疗，7例（53.8%）接受经皮雌激素治疗。在最后一次对照时，比较两组接受雌激素治疗患者的实足年龄（CA）差值与骨龄（BA）差值之比（ΔCA/ΔBA）。经皮雌激素治疗组的ΔCA/ΔBA比值显著更高（p = 0.005）。这些结果表明，经皮雌激素治疗的TS女孩骨龄进展较慢。
经皮雌激素治疗时骨龄进展不那么显著，这与乳房充分发育有关。
