Li Ying, Yan Guofeng, Zhang Liang, He Sailing
Opt Express. 2015 Apr 6;23(7):9483-93. doi: 10.1364/OE.23.009483.
We present a compact microfluidic flowmeter based on Fabry-Perot interferometer (FPI). The FPI was composed by a pair of fiber Bragg grating reflectors and a micro Co(2+)-doped optical fiber cavity, acting as a "hot-wire" sensor. Microfluidic channels made from commercial silica capillaries were integrated with the FPIs on a chip to realize flow-rate sensing system. By utilizing a tunable pump laser with wavelength of 1480 nm, the proposed flowmeter was experimentally demonstrated. The flow rate of the liquid sample is determined by the induced resonance wavelength shift of the FPI. The effect of the pump power, microfluidic channel scale and temperature on the performance of our flowmeter was investigated. The dynamic response was also measured under different flow-rate conditions. The experimental results achieve a sensitivity of 70 pm/(μL/s), a dynamic range up to 1.1 μL/s and response time in the level of seconds, with a spatial resolution ~200 μm. Such good performance renders the sensor a promising supplementary component in microfluidic biochemical sensing system. Furthermore, simulation modal was built up to analyze the heat distribution of the "hot-wire" cavity and optimize the FPI structure as well.
我们展示了一种基于法布里-珀罗干涉仪(FPI)的紧凑型微流体流量计。该FPI由一对光纤布拉格光栅反射器和一个微钴(2+)掺杂光纤腔组成,用作“热线”传感器。由商用石英毛细管制成的微流体通道与芯片上的FPI集成在一起,以实现流量传感系统。通过使用波长为1480nm的可调谐泵浦激光器,对所提出的流量计进行了实验验证。液体样品的流速由FPI诱导的共振波长偏移确定。研究了泵浦功率、微流体通道尺度和温度对我们流量计性能的影响。还在不同流速条件下测量了动态响应。实验结果实现了70pm/(μL/s)的灵敏度、高达1.1μL/s的动态范围和秒级的响应时间,空间分辨率约为200μm。如此良好的性能使该传感器成为微流体生化传感系统中有前景的补充组件。此外,还建立了模拟模型来分析“热线”腔的热分布并优化FPI结构。