Alshehry Nawal F, Al-Huneini Mohammed, Lipton Jeffrey H, Michelis Fotios V
Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ont., Canada.
Acta Haematol. 2015;134(3):161-7. doi: 10.1159/000375150. Epub 2015 May 9.
Lymphoproliferative disorders presenting simultaneously with or subsequent to the occurrence of chronic myeloid leukemia (CML) have rarely been reported. Herein, we report 8 cases of a variety of lymphoproliferative conditions associated with CML at different times during the course of the disease. All 8 patients were treated with tyrosine kinase inhibitors at some point during the course of their illness. The literature regarding the uncommon association of these apparently unrelated disorders is reviewed as well as the possible underlying mechanisms that could be associated with this phenomenon.
同时出现或在慢性髓性白血病（CML）发生后出现的淋巴增殖性疾病鲜有报道。在此，我们报告8例在疾病过程中不同时间与CML相关的各种淋巴增殖性疾病。所有8例患者在病程中的某个时间点均接受了酪氨酸激酶抑制剂治疗。本文回顾了关于这些明显无关疾病罕见关联的文献，以及可能与此现象相关的潜在机制。
