墨西哥学龄儿童载脂蛋白E变异体与肥胖相关特征之间的关联。

Association between Apolipoprotein E Variants and Obesity-Related Traits in Mexican School Children.

作者信息

Rodríguez-Carmona Yanelli, Pérez-Rodríguez Marcela, Gámez-Valdez Eli, López-Alavez Francisco J, Hernández-Armenta Claudia I, Vega-Monter Norma, Leyva-García Gerardo, Monge-Cázares Tulia, Barrera Valencia Daniela, Balderas Monroy Marisol, Pfeffer Frania, Meléndez Guillermo, Pérez Lizaur Ana Bertha, Pardío Jeanette, Tejero María Elizabeth

机构信息

Universidad Autónoma Metropolitana, Mexico City, Mexico.

出版信息

J Nutrigenet Nutrigenomics. 2014;7(4-6):243-51. doi: 10.1159/000381345. Epub 2015 May 6.

DOI:10.1159/000381345

PMID:25968937

Abstract

BACKGROUND/AIM: Genetic variation in apolipoprotein E (ApoE) has a key role in lipid metabolism. However, its contribution to the amount and distribution of body fat is under investigation. The aim of this study was to analyze the association between genetic variation in ApoE and obesity-related traits in Mexican school children.

MATERIAL AND METHODS

Anthropometric, body composition and physical activity measures were conducted using standard methods in 300 children (177 girls/123 boys) who fulfilled the inclusion criteria. DNA was isolated from saliva. ApoE genotypes were analyzed by allelic discrimination. The association between variation in ApoE and anthropometric and body composition measures was investigated using the General Linear Model.

RESULTS

The mean±SD values for age, body mass index (BMI) and waist circumference (WC) were 9.05±0.80 years, 19.01±3.83 and 67.98±10.97 cm, respectively. Approximately 46% of the participants were overweight or obese. A significant association between ApoE isoforms and WC was found after controlling for age, sex and the percentage of physical activity (p=0.025). Significant main effects were found for vigorous physical activity and light physical activity influencing the adiposity-related BMI (p<0.001) and WC (p=0.044), respectively.

CONCLUSIONS

Variation in ApoE and physical activity intensity were associated with adiposity-related phenotypes in Mexican school children.

摘要

背景/目的：载脂蛋白E（ApoE）的基因变异在脂质代谢中起关键作用。然而，其对体脂量和分布的影响仍在研究中。本研究的目的是分析墨西哥学龄儿童中ApoE基因变异与肥胖相关性状之间的关联。

材料与方法

采用标准方法对300名符合纳入标准的儿童（177名女孩/123名男孩）进行人体测量、身体成分和身体活动测量。从唾液中提取DNA。通过等位基因鉴别分析ApoE基因型。使用一般线性模型研究ApoE变异与人体测量和身体成分测量之间的关联。

结果

年龄、体重指数（BMI）和腰围（WC）的平均值±标准差分别为9.05±0.80岁、19.01±3.83和67.98±10.97厘米。约46%的参与者超重或肥胖。在控制年龄、性别和身体活动百分比后，发现ApoE异构体与WC之间存在显著关联（p = 0.025）。发现剧烈身体活动和轻度身体活动分别对与肥胖相关的BMI（p < 0.001）和WC（p = 0.044）有显著的主要影响。