Yamamoto Takahiro, Malavasi Elisa, Archer John R H, Dargan Paul I, Wood David M
aClinical Toxicology, Guy's and St Thomas' NHS Foundation Trust and King's Health Partners bKing's College London, London, UK cPoison Control Center Bergamo, Papa Giovanni XXIII Hospital, Bergamo, Italy.
Eur J Emerg Med. 2016 Dec;23(6):425-429. doi: 10.1097/MEJ.0000000000000277.
The aim of this study was to establish a management protocol for body stuffers presenting to the emergency department.
This is a retrospective observational case series of patients presenting to the emergency department of a large inner-city hospital as 'body stuffers' during the period between 1 January 2006 and 31 October 2011, irrespective of the type of drug ingested. We reviewed demographic data, ingestion characteristics, clinical progress and outcome.
A total of 126 patients were included in the study, with a mean age of 31±8.10 years (range 15-58 years), among whom 106 were male (84%). Drugs ingested were as follows: heroin (n=61, 48%), cocaine (n=58, 46%), other drugs (n=20, 16%) and unknown (n=10, 8%). Of the patients, 23 (18%) ingested more than one drug. At presentation, 96 had features of drug toxicity. The presence of depressant drug toxidrome was more commonly observed among heroin users, but stimulant drug toxidromes were seen across all groups. Of the patients, 12 developed changes in clinical state, with a mean time to development of symptoms of 2 h 50 min±1 h 39 min (range from 1 h 0 min to 5 h 36 min). Abdominal radiography showed the presence of foreign bodies in 8% of the tests performed, and packets were recovered from one patient who underwent gut decontamination.
Patients developed new or worsening features of drug toxicity within 6 h of presentation. Toxidromes observed are often not drug/class specific, and treatment including gut decontamination and radiography do not aid in expediting discharge. We propose an observation period of 6 h from the time of admission as the time required if the patient is asymptomatic or there is resolution of presenting signs and symptoms.
本研究旨在建立针对前往急诊科的体内藏毒者的管理方案。
这是一项回顾性观察病例系列研究,研究对象为2006年1月1日至2011年10月31日期间前往一家大型市中心医院急诊科的“体内藏毒者”,无论所摄入药物的类型如何。我们回顾了人口统计学数据、摄入特征、临床进展和结局。
本研究共纳入126例患者,平均年龄为31±8.10岁(范围15 - 58岁),其中106例为男性(84%)。摄入的药物如下:海洛因(n = 61,48%)、可卡因(n = 58,46%)、其他药物(n = 20,16%)和不明药物(n = 10,8%)。其中23例(18%)患者摄入了不止一种药物。就诊时,96例有药物中毒特征。镇静药物中毒综合征在海洛因使用者中更常见,但所有组均可见兴奋剂药物中毒综合征。12例患者临床状态出现变化,症状出现的平均时间为2小时50分钟±1小时39分钟(范围从1小时0分钟至5小时36分钟)。腹部X线检查显示,8%的检查发现有异物,1例接受肠道去污的患者排出了包裹。
患者在就诊后6小时内出现新的或恶化的药物中毒特征。观察到的中毒综合征通常并非特定于药物/类别,包括肠道去污和X线检查在内的治疗无助于加快出院。我们建议,若患者无症状或当前体征和症状已缓解,则自入院起观察6小时作为所需时间。