Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev The Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev Faculty of Health and Medical Sciences, University of Copenhagen.
Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev The Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev Faculty of Health and Medical Sciences, University of Copenhagen The Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Ann Oncol. 2015 Aug;26(8):1784-90. doi: 10.1093/annonc/mdv231. Epub 2015 May 12.
Immunoglobulin E (IgE) is produced by plasma cells, often as part of an allergic immune response. It is currently unknown whether plasma IgE levels are associated with risk of cancer in individuals from the general population. We tested the hypothesis that high levels of plasma total IgE are associated with overall risk of cancer and with risk of specific cancers.
Plasma total IgE was measured in 37 747 individuals from the general population, and the participants were followed prospectively for up to 30 years. All statistical tests were two-sided.
During a mean follow-up of 7 years, a first cancer was diagnosed in 3454 participants. The multivariable adjusted hazard ratio for a 10-fold higher level of IgE was 1.05 [95% confidence interval (CI) 1.00-1.11; P = 0.04] for any cancer, 0.44 (0.30-0.64; P = 0.00002) for chronic lymphocytic leukemia (CLL), 0.53 (0.33-0.84; P = 0.007) for multiple myeloma, 1.54 (1.04-2.29; P = 0.03) for other non-Hodgkin lymphoma, 1.38 (1.04-1.84; P = 0.03) for cancer of the oral cavity and pharynx, and 1.12 (1.00-1.25; P = 0.05) for lung cancer. The findings for CLL and multiple myeloma were generally robust; however, after correcting for 27 multiple comparisons only the finding for CLL remained significant.
High levels of plasma total IgE were associated with low risk of CLL and possibly of multiple myeloma, without convincing evidence for high risk of any cancer type.
免疫球蛋白 E（IgE）由浆细胞产生，通常是过敏免疫反应的一部分。目前尚不清楚血浆 IgE 水平是否与普通人群中癌症的风险有关。我们检验了以下假说：即高水平的血浆总 IgE 与癌症的总体风险以及特定癌症的风险相关。
在普通人群的 37747 名个体中测量了血浆总 IgE，参与者前瞻性随访长达 30 年。所有统计检验均为双侧检验。
在平均 7 年的随访期间，3454 名参与者中诊断出了首例癌症。经多变量校正后，IgE 水平升高 10 倍，癌症风险比为 1.05（95%置信区间为 1.00-1.11；P=0.04），所有癌症、慢性淋巴细胞白血病（CLL）、多发性骨髓瘤、其他非霍奇金淋巴瘤、口腔和咽癌和肺癌的风险比分别为 0.44（0.30-0.64；P=0.00002）、0.53（0.33-0.84；P=0.007）、1.54（1.04-2.29；P=0.03）、1.38（1.04-1.84；P=0.03）和 1.12（1.00-1.25；P=0.05）。CLL 和多发性骨髓瘤的发现结果基本稳健；然而，在对 27 个多重比较进行校正后，仅 CLL 的发现结果仍然显著。
高水平的血浆总 IgE 与 CLL 风险降低相关，可能与多发性骨髓瘤风险降低相关，但尚无充分证据表明其与任何癌症类型的风险升高相关。
