Sokova O I, Pogosianz H E
Institute of Carcinogenesis, Academy of Medical Sciences, Moscow, USSR.
Arch Geschwulstforsch. 1989;59(6):399-406.
The karyotypes of 30 tumors (sarcomas and adenocarcinomas) induced with methylcholanthrene in Djungarian hamsters (Phodopus sungorus campbelli) have been investigated. In 23 tumors structural changes of the short arm of X-chromosome (Xp+ or Xp = type) were revealed. Non-random rearrangements of 3p, 7q and 8q were also observed. Other structural or numerical changes of the karyotype were accidential. For majority of tumors the presence of chromosome markers with long homogeneously staining regions or double minutes, structures are known as cytological manifestation of gene amplification, was typical. Induced tumors of the Djungarian hamster might serve as an interesting tool for studies of relationship of somatic cell genetic changes to different aspects of chemical carcinogenesis.
对在黑线仓鼠（Phodopus sungorus campbelli）中由甲基胆蒽诱导产生的30个肿瘤（肉瘤和腺癌）的核型进行了研究。在23个肿瘤中发现了X染色体短臂的结构变化（Xp+或Xp=型）。还观察到3p、7q和8q的非随机重排。核型的其他结构或数量变化是偶然的。对于大多数肿瘤来说，存在具有长均匀染色区或双微体的染色体标记是典型的，这些结构是基因扩增的细胞学表现。黑线仓鼠的诱导肿瘤可能是研究体细胞遗传变化与化学致癌不同方面关系的一个有趣工具。
