Ebert A, Lenk H, Geyer J, Tanneberger S
Zentralinstitut für Krebsforschung der Akademie der Wissenschaften der DDR, Robert-Rössle-Institut, Berlin-Buch.
Arch Geschwulstforsch. 1989;59(6):455-61.
An organ culture assay for in vitro chemosensitivity testing was used to predict clinical responses of various tumors to antineoplastic chemotherapy. 9 patients with advanced mammary carcinomas, 7 patients with metastatic malignant melanomas, 1 patient with advanced ovarian cancer, 1 with bronchogenic carcinoma, 1 with metastatic leiomyosarcoma and 1 patient with a metastatic carcinoma of the sweat gland were included in the study. 20 in vitro-in vivo correlations were evaluable. 5/9 of the mammary carcinomas showed an objective response, 0/7 malignant melanomas were sensitive in vivo. Further investigations have to assess the value of chemosensitivity assays to predict clinical response for patients with solid tumors.
一种用于体外化学敏感性测试的器官培养试验被用于预测各种肿瘤对抗肿瘤化疗的临床反应。该研究纳入了9例晚期乳腺癌患者、7例转移性恶性黑色素瘤患者、1例晚期卵巢癌患者、1例支气管癌患者、1例转移性平滑肌肉瘤患者和1例汗腺转移性癌患者。可评估20例体外-体内相关性。9例乳腺癌中有5例显示出客观反应，7例恶性黑色素瘤中无1例在体内敏感。进一步的研究必须评估化学敏感性测定对预测实体瘤患者临床反应的价值。
