Bio301：一个基于网络的EST注释管道，有助于功能比较研究。
Bio301: A Web-Based EST Annotation Pipeline That Facilitates Functional Comparison Studies.
作者信息
Chen Yen-Chen, Chen Yun-Ching, Lin Wen-Dar, Hsiao Chung-Der, Chiu Hung-Wen, Ho Jan-Ming
机构信息
Institute of Information Science, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 115, Taiwan.
Department of Biomedical Engineering, The Whitaker Biomedical Engineering Institute at Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA.
出版信息
ISRN Bioinform. 2011 Sep 27;2012:139842. doi: 10.5402/2012/139842. eCollection 2012.
In this postgenomic era, a huge volume of information derived from expressed sequence tags (ESTs) has been constructed for functional description of gene expression profiles. Comparative studies have become more and more important to researchers of biology. In order to facilitate these comparative studies, we have constructed a user-friendly EST annotation pipeline with comparison tools on an integrated EST service website, Bio301. Bio301 includes regular EST preprocessing, BLAST similarity search, gene ontology (GO) annotation, statistics reporting, a graphical GO browsing interface, and microarray probe selection tools. In addition, Bio301 is equipped with statistical library comparison functions using multiple EST libraries based on GO annotations for mining meaningful biological information.
在这个后基因组时代，已经构建了大量源自表达序列标签（EST）的信息，用于基因表达谱的功能描述。比较研究对生物学研究人员而言变得越来越重要。为了促进这些比较研究，我们在一个集成的EST服务网站Bio301上构建了一个带有比较工具的用户友好型EST注释管道。Bio301包括常规的EST预处理、BLAST相似性搜索、基因本体（GO）注释、统计报告、图形化GO浏览界面以及微阵列探针选择工具。此外，Bio301还配备了基于GO注释使用多个EST文库的统计库比较功能，用于挖掘有意义的生物学信息。
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