Khlystov V V, Pavlenko V S, Khavinson V Kh, Morozov V G, Slepushkin V D
Arkh Patol. 1989;51(9):27-31.
Cardiolin therapy influence on the periinfarction zone cardiomyocyte ultrastructure, sarcolemma permeability for colloidal lantan, myocardium energy level were studied in 25 white noninbred rats with experimental myocardial infarction. 6 hours after coronary occlusion ultrastructural damage in treated rats was less pronounced and mitochondria energy efficiency ratio was higher than those in the control group. 24 hours after the occlusion the tendency to normalization of the cardiomyocyte damage in treated rat myocardium was demonstrated, while in non-treated animals ischemic damage becomes irreversible, this being confirmed by the test with colloidal lantan. Cardiolin therapy prevents the infarction zone expansion by decreasing ischemic damage of periinfarction cardiomyocytes and by stimulating regeneration processes in these cells.
在25只患有实验性心肌梗死的白色非近交系大鼠中，研究了Cardiolin疗法对梗死周边区心肌细胞超微结构、胶体镧对肌膜的通透性以及心肌能量水平的影响。冠状动脉闭塞6小时后，治疗组大鼠的超微结构损伤较轻，线粒体能量效率比高于对照组。闭塞24小时后，治疗组大鼠心肌细胞损伤有恢复正常的趋势，而未治疗的动物缺血损伤变得不可逆，胶体镧试验证实了这一点。Cardiolin疗法通过减少梗死周边心肌细胞的缺血损伤和刺激这些细胞的再生过程来防止梗死区扩大。
