Ganzetti Giulia, Simonetti Oriana, Campanati Anna, Giuliodori Katia, Scocco Vitangelo, Brugia Marina, Tocchini Massimo, Offidani Anamaria
Anna Campanati, MD, Via conca 71, 60020 Ancona, Italy;
Acta Dermatovenerol Croat. 2015;23(1):19-22.
Osteopontin (OPN) is a multifunctional glycophosphoprotein secreted by many cell types, including osteoblasts, lymphocites, macrophages, epithelial cells, and vascular smooth muscle cells. It has been implicated in many physiological and pathological processes, such as cell-mediated immunity, inflammation, cell survival, and tumor invasion and metastasis. Osteopontin has multiple emerging roles in cutaneous biology and pathology and OPN involvement has been emphasized in Th1-mediated diseases such as psoriasis. Alopecia areata (AA) is a form of non-scarring hair loss affecting anagen stage hair follicles with a multifactorial autoimmune pathogenesis characterized by a prevalent Th1 cytokine profile. Given the role of osteopontin in Th1-mediated inflammation, we have postulated that OPN may be involved in AA pathogenesis. The aim of our study was to investigate plasma OPN level in alopecia areata before and after DPCP treatment. Our results showed that OPN plasma levels in patients with alopecia areata were higher than in healthy controls, but patients achieving complete recovery after DPCP treatment did not show a statistically significant reduction of OPN plasma levels.
骨桥蛋白（OPN）是一种由多种细胞类型分泌的多功能糖磷蛋白，这些细胞类型包括成骨细胞、淋巴细胞、巨噬细胞、上皮细胞和血管平滑肌细胞。它参与了许多生理和病理过程，如细胞介导的免疫、炎症、细胞存活以及肿瘤侵袭和转移。骨桥蛋白在皮肤生物学和病理学中具有多种新出现的作用，并且在银屑病等Th1介导的疾病中，骨桥蛋白的参与已得到强调。斑秃（AA）是一种非瘢痕性脱发，影响生长期毛囊，其发病机制为多因素自身免疫，以Th1细胞因子谱为主。鉴于骨桥蛋白在Th1介导的炎症中的作用，我们推测骨桥蛋白可能参与斑秃的发病机制。我们研究的目的是调查二苯环丙烯酮（DPCP）治疗前后斑秃患者血浆骨桥蛋白水平。我们的结果显示，斑秃患者的血浆骨桥蛋白水平高于健康对照，但DPCP治疗后实现完全缓解的患者血浆骨桥蛋白水平并未出现统计学上的显著降低。
