van Teeffelen Augustinus, van der Heijden Jantien, van der Ham David, Schaaf Jelle M, van Kuijk Sander, Ravelli Anita C J, Pajkrt Eva, Willekes Christine, Nijhuis Jan, Mol Ben Willem M
Department of Obstetrics and Gynecology, Maastricht University Medical Center, Maastricht, The Netherlands.
Department of Obstetrics and Gynecology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands.
Am J Perinatol. 2015 Oct;32(12):1112-8. doi: 10.1055/s-0035-1548539. Epub 2015 May 13.
The aim of the study was to assess the impact of gestational age (GA) at rupture and latency on perinatal outcome after midtrimester prelabor rupture of membranes (PROM).
We obtained data on singleton pregnancies from 22 weeks onwards from the Dutch Perinatal Registry from 1999 to 2007, congenital abnormalities were excluded. In women with PROM before 26 weeks, we studied the impact of GA at rupture and latency on perinatal mortality and morbidity.
A total of 1,233 pregnancies were included. Higher GA at delivery appeared to increase the probability of survival without morbidity, GA at PROM did not. In pregnancies of minimum 22 weeks GA, there appeared to be no clear relationship between earlier GA at PROM and adverse outcome.
Longer latency and early GA at PROM seem to have limited impact in patients delivering after 22 weeks.
本研究旨在评估孕中期胎膜早破（PROM）时的孕周（GA）和潜伏期对围产期结局的影响。
我们从1999年至2007年的荷兰围产期登记处获取了自22周起的单胎妊娠数据，排除了先天性异常情况。对于26周前发生PROM的女性，我们研究了胎膜破裂时的孕周和潜伏期对围产期死亡率和发病率的影响。
共纳入1233例妊娠。分娩时较高的孕周似乎会增加无发病存活的概率，而胎膜早破时的孕周则不会。在孕周至少为22周的妊娠中，胎膜早破时较早的孕周与不良结局之间似乎没有明确的关系。
较长的潜伏期和胎膜早破时较早的孕周对22周后分娩的患者影响似乎有限。
