NADH 及 NADPH 连接的水钴胺素还原酶存在于大鼠肝脏的线粒体膜和微粒体膜中。
NADH- and NADPH-linked aquacobalamin reductases occur in both mitochondrial and microsomal membranes of rat liver.
作者信息
Watanabe F, Nakano Y, Maruno S, Tachikake N, Tamura Y, Kitaoka S
机构信息
Laboratory of Nutrition and Food Science, College of Hagoromo-gakuen, Osaka, Japan.
出版信息
Biochem Biophys Res Commun. 1989 Dec 15;165(2):675-9. doi: 10.1016/s0006-291x(89)80018-x.
To elucidate the mechanism for the synthesis of the coenzyme forms of cobalamin in mammals, rat liver aquacobalamin reductase was partially characterized. Rat liver contained both NADH- and NADPH-linked aquacobalamin reductases. The NADH-linked enzyme was distributed in the mitochondria (approx. 40%) and microsomes (60%), identical to the distribution of the NADPH-linked enzyme. The two mitochondrial NADH- and NADPH-linked enzymes were located inside of the outer membrane.
为阐明哺乳动物中钴胺素辅酶形式的合成机制，对大鼠肝脏水钴胺素还原酶进行了部分特性鉴定。大鼠肝脏含有与NADH和NADPH相关的水钴胺素还原酶。与NADPH相关的酶分布相同，与NADH相关的酶分布于线粒体（约40%）和微粒体（60%）中。两种线粒体中与NADH和NADPH相关的酶位于外膜内侧。
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