Rose S, Nomoto M, Jenner P, Marsden C D
MRC Movement Disorders Research Group, University Department of Neurology, London, U.K.
Biochem Pharmacol. 1989 Nov 1;38(21):3677-81. doi: 10.1016/0006-2952(89)90572-8.
Acute treatment of common marmosets with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) caused an initial profound akinesia and other motor deficits. However, over the following months akinesia gradually disappeared although the animals remained clumsy and poorly coordinated. At 10 days following MPTP treatment there was a profound decrease in the dopamine, HVA and DOPAC content of the caudate nucleus, putamen and nucleus accumbens. By 3-4 months following MPTP treatment the animals had largely recovered from their akinesia, but the caudate nucleus and putamen dopamine, HVA and DOPAC content remained low. In contrast, the dopamine content of the nucleus accumbens had returned towards normal and the metabolite levels were higher than at 10 days. No overall alterations in 5HT or 5HIAA levels were observed at either time point. The transient and reversible nature of dopamine loss in the nucleus accumbens may contribute to the initial profound akinesia exhibited by common marmosets treated with MPTP. The restoration of dopamine levels in the nucleus accumbens may be partially responsible for the subsequent recovery of motor function that occurs in MPTP-treated marmosets.
用1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）对普通狨猴进行急性处理，会导致最初严重的运动不能及其他运动缺陷。然而，在接下来的几个月里，运动不能逐渐消失，尽管动物仍然笨拙且协调性差。MPTP处理后10天，尾状核、壳核和伏隔核中的多巴胺、高香草酸（HVA）和3,4-二羟基苯乙酸（DOPAC）含量大幅下降。MPTP处理后3至4个月，动物的运动不能已基本恢复，但尾状核和壳核中的多巴胺、HVA和DOPAC含量仍较低。相比之下，伏隔核中的多巴胺含量已恢复至正常，且代谢物水平高于处理后10天。在两个时间点均未观察到5-羟色胺（5HT）或5-羟吲哚乙酸（5HIAA）水平的总体变化。伏隔核中多巴胺损失的短暂性和可逆性可能导致了用MPTP处理的普通狨猴最初出现的严重运动不能。伏隔核中多巴胺水平的恢复可能部分解释了MPTP处理的狨猴随后运动功能的恢复。
