Suzuki K T, Takahashi K, Tamagawa H, Shimojo N
National Institute for Environmental Studies, Ibaraki, Japan.
Biochem Pharmacol. 1989 Nov 15;38(22):4053-60. doi: 10.1016/0006-2952(89)90686-2.
Pregnancy-associated changes in concentrations and distributions of selected essential elements were examined in the blood and tissues of rats. Concentrations of copper (Cu) and zinc (Zn) in the kidneys of dams significantly decreased with gestational age and recovered after delivery. Distribution profiles of multi-elements in the supernatant of the kidneys indicated that Cu and Zn bound to metallothionein decreased with gestational age without affecting their distributions to other components. Although concentrations of Cu and Zn in the liver did not show significant changes during gestational period, Zn bound to metallothionein decreased with gestational age. Plasma concentrations of Cu, iron, phosphorus, sulfur, Zn and other elements were altered by the physiological change, some of those chemical forms being assigned.
在大鼠的血液和组织中检测了与妊娠相关的特定必需元素的浓度和分布变化。随着胎龄增加，母鼠肾脏中铜（Cu）和锌（Zn）的浓度显著降低，分娩后恢复。肾脏上清液中多种元素的分布情况表明，与金属硫蛋白结合的Cu和Zn随胎龄降低，而它们向其他成分的分布未受影响。虽然孕期肝脏中Cu和Zn的浓度没有显著变化，但与金属硫蛋白结合的Zn随胎龄降低。生理变化改变了血浆中Cu、铁、磷、硫、Zn和其他元素的浓度，其中一些化学形态已得到确定。
