Kohri Kumiko, Yoshida Eiko, Yasuike Shuji, Fujie Tomoya, Yamamoto Chika, Kaji Toshiyuki
Faculty of Pharmaceutical Sciences, Tokyo University of Science.
J Toxicol Sci. 2015 Jun;40(3):321-7. doi: 10.2131/jts.40.321.
Organic-inorganic hybrid molecules, which are composed of an organic structure and metal(s), are indispensable for synthetic chemical reactions; however, their toxicity has been incompletely understood. In the present study, we discovered two cytotoxic organobismuth compounds whose cytotoxicity diminished upon replacement of the intramolecular bismuth atom with an antimony atom. The intracellular accumulation of the organobismuth compounds was much higher than that of the organoantimony compounds with the corresponding organic structures. We also showed that both the organic structure and bismuth atom are required for certain organobismuth compounds to exert their cytotoxic effect, suggesting that the cytotoxicity of such a compound is a result of an interaction between the organic structure and the bismuth atom. The present data suggest that organobismuth compounds with certain molecular structures exhibit cytotoxicity via an interaction between the molecular structure and the bismuth atom, and this cytotoxicity can be diminished by replacing the bismuth atom with an antimony atom, resulting in lower intracellular accumulation.
由有机结构和金属组成的有机-无机杂化分子对于合成化学反应不可或缺；然而，它们的毒性尚未被完全了解。在本研究中，我们发现了两种具有细胞毒性的有机铋化合物，当分子内的铋原子被锑原子取代时，其细胞毒性减弱。有机铋化合物在细胞内的积累量远高于具有相应有机结构的有机锑化合物。我们还表明，某些有机铋化合物发挥其细胞毒性作用需要有机结构和铋原子两者，这表明此类化合物的细胞毒性是有机结构与铋原子之间相互作用的结果。目前的数据表明，具有特定分子结构的有机铋化合物通过分子结构与铋原子之间的相互作用表现出细胞毒性，并且通过用锑原子取代铋原子可以减弱这种细胞毒性，从而导致细胞内积累量降低。
