癌症中的去泛素化酶
Deubiquitinases in cancer.
作者信息
Wei Rongbin, Liu Xiaodong, Yu Weixin, Yang Tianshu, Cai Wenping, Liu Junjun, Huang Xiao, Xu Guo-tong, Zhao Shouliang, Yang Jianhua, Liu Shangfeng
机构信息
Department of Ophthalmology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P. R. China.
Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, P. R. China.
出版信息
Oncotarget. 2015 May 30;6(15):12872-89. doi: 10.18632/oncotarget.3671.
Abstract
Deubiquitinases are deubiquitinating enzymes (DUBs), which remove ubiquitin from proteins, thus regulating their proteasomal degradation, localization and activity. Here, we discuss DUBs as anti-cancer drug targets.
摘要
去泛素化酶是一种去泛素化酶（DUBs），可从蛋白质中去除泛素，从而调节其蛋白酶体降解、定位和活性。在此，我们讨论将去泛素化酶作为抗癌药物靶点。
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