Dadlani Ravi, Dadlani Reena, Ghosal Nandita, Hegde Alangar
Department of Neurosurgery, Sri Sathya Sai Institute of Higher Medical Sciences, Bengaluru, Karnataka, India.
Department of Microbiology, Vydehi Institute of Medical Sciences and Research Center, Bengaluru, Karnataka, India.
Asian J Neurosurg. 2015 Apr-Jun;10(2):177-80. doi: 10.4103/1793-5482.154988.
Ventriculoperitoneal (VP) shunt surgery is probably the commonest surgical procedure in neurosurgery. Belying its technical simplicity is the myriad complications associated with it. Shunt malfunction is a common complication associated with this surgery, second only to shunt related infections, which may be associated with it. Sterile cerebrospinal fluid (CSF) eosinophilia (CE) has been reported with VP shunts, which may or may not be related to the dysfunction. Eosinophilia in the CSF has also been associated with a number of other conditions including parasitic infestations in the brain. This may be unrelated to the shunt surgery. We present a case of a child, operated earlier for hydrocephalus, who presented with sub-acute loss of vision and bilateral oculomotor paresis. CSF from a chamber tap revealed eosinophilia. The commonest presenting symptom of shunt malfunction is raised intracranial pressure. There are no reports in the literature of VP shunt malfunction presenting with bilateral oculomotor paresis and decreased visual acuity. The associated CE complicated the clinical picture, especially since the initial brain radiology was normal. We discuss the clinical differential diagnosis of this very interesting presentation, management dilemmas and outcome in this child. This rare clinical presentation was found to be the result of a shunt malfunction and not due to any rare parasitic infestation of the brain. Occam's razor dictates that the simplest explanation in a given situation is usually the most accurate, as is seen in this case.
脑室腹腔(VP)分流术可能是神经外科最常见的手术操作。尽管其技术看似简单,却伴随着无数并发症。分流功能障碍是该手术常见的并发症,仅次于与分流相关的感染,且可能与之相关。有报道称VP分流术会出现无菌性脑脊液(CSF)嗜酸性粒细胞增多(CE),这可能与分流功能障碍有关,也可能无关。脑脊液中的嗜酸性粒细胞增多还与许多其他情况有关,包括脑部寄生虫感染。这可能与分流手术无关。我们报告一例患儿,此前因脑积水接受手术,现出现亚急性视力丧失和双侧动眼神经麻痹。脑室穿刺获取的脑脊液显示嗜酸性粒细胞增多。分流功能障碍最常见的症状是颅内压升高。文献中尚无VP分流功能障碍表现为双侧动眼神经麻痹和视力下降的报道。相关的CE使临床情况复杂化,尤其是最初的脑部影像学检查正常时。我们讨论了这个非常有趣表现的临床鉴别诊断、管理困境及该患儿的预后。发现这种罕见的临床表现是分流功能障碍的结果,而非由于任何罕见的脑部寄生虫感染。正如本例所示,奥卡姆剃刀原理表明,在特定情况下最简单的解释通常是最准确的。