Hosseini Sara Sadat, Yamini Bakhtiar, Ichkitidze Levan, Asadi Majid, Fernandez Julie, Gholampour Seifollah
Department of Neurological Surgery, University of Chicago, Chicago, IL 60637, USA.
Institute of Biomedical Systems of National Research University of Electronic Technology (MIET), 124498 Moscow, Russia.
Nanomaterials (Basel). 2023 Jan 24;13(3):473. doi: 10.3390/nano13030473.
The present study aims to use enhanced ionic polymer-metal composites (IPMC) as an artificial muscle (a soft-active actuator) to restore eyelid movement of patients with ptosis. The previous eyelid movement mechanisms contained drawbacks, specifically in the lower eyelid. We used finite element analysis (FEA) to find the optimal mechanism among two different models (A and B). In addition to common electrodes of IPMC (gold and platinum), the bovine serum albumin (BSA) and microcrystalline cellulose (MCC) polymers, with optimal weight percentages of carbon nanotube (CNT) nanofiller, were also utilized as non-metallic electrodes to improve the efficiency of the IPMC actuator. In both models, IPMC with nanocomposite electrodes had higher efficiency as compared to the metallic electrodes. In model A, which moved eyelids indirectly, IPMC with MCC-CNT electrode generated a higher force (25.4%) and less stress (5.9 times) as compared to IPMC with BSA-CNT electrode. However, the use of model A (even with IPMCs) with nanocomposite electrodes can have limitations such as possible malposition issues in the eyelids (especially lower). IPMC with MCC-CNT nanocomposite electrode under model B, which moved eyelids directly, was the most efficient option to restore eyelid movement. It led to higher displacements and lower mechanical stress damage as compared to the BSA-CNT. This finding may provide surgeons with valuable data to open a window in the treatment of patients with ptosis.
本研究旨在使用增强型离子聚合物-金属复合材料(IPMC)作为人工肌肉(一种软活性致动器)来恢复上睑下垂患者的眼睑运动。先前的眼睑运动机制存在缺陷,特别是在下眼睑方面。我们使用有限元分析(FEA)在两种不同模型(A和B)中找到最佳机制。除了IPMC的常见电极(金和铂)外,还使用了具有最佳重量百分比碳纳米管(CNT)纳米填料的牛血清白蛋白(BSA)和微晶纤维素(MCC)聚合物作为非金属电极,以提高IPMC致动器的效率。在两种模型中,与金属电极相比,具有纳米复合电极的IPMC效率更高。在间接移动眼睑的模型A中,与具有BSA-CNT电极的IPMC相比,具有MCC-CNT电极的IPMC产生的力更高(25.4%)且应力更小(5.9倍)。然而,使用具有纳米复合电极的模型A(即使使用IPMC)可能存在局限性,例如眼睑(尤其是下眼睑)可能出现位置不当的问题。在直接移动眼睑的模型B下,具有MCC-CNT纳米复合电极的IPMC是恢复眼睑运动的最有效选择。与BSA-CNT相比,它导致更高的位移和更低的机械应力损伤。这一发现可能为外科医生提供有价值的数据,为上睑下垂患者的治疗打开一扇窗。