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Tif1γ regulates the TGF-β1 receptor and promotes physiological aging of hematopoietic stem cells.Tif1γ 调节 TGF-β1 受体并促进造血干细胞的生理衰老。
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Musashi-2 controls cell fate, lineage bias, and TGF-β signaling in HSCs.Musashi-2 控制造血干细胞的细胞命运、谱系偏向和 TGF-β 信号通路。
J Exp Med. 2014 Jan 13;211(1):71-87. doi: 10.1084/jem.20130736. Epub 2014 Jan 6.
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Complex and context dependent regulation of hematopoiesis by TGF-beta superfamily signaling.转化生长因子-β超家族信号对造血作用的复杂且依赖于背景的调控
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TGF-beta as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation.转化生长因子-β作为一种候选的骨髓龛信号，可诱导造血干细胞休眠。
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A cross-talk between stromal cell-derived factor-1 and transforming growth factor-beta controls the quiescence/cycling switch of CD34(+) progenitors through FoxO3 and mammalian target of rapamycin.基质细胞衍生因子-1与转化生长因子-β之间的相互作用通过FoxO3和雷帕霉素哺乳动物靶标控制CD34(+)祖细胞的静止/增殖转换。
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Smad4 is critical for self-renewal of hematopoietic stem cells.Smad4对造血干细胞的自我更新至关重要。
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Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway.造血作用由转化生长因子β（TGFβ）信号通路中不同的TIF1γ和Smad4分支所控制。
Cell. 2006 Jun 2;125(5):929-41. doi: 10.1016/j.cell.2006.03.045.

转化生长因子-β信号传导及其在造血干细胞调节中的作用。

TGF-β signaling and its role in the regulation of hematopoietic stem cells.

作者信息

Vaidya Anuradha, Kale Vaijayanti P

机构信息

Symbiosis School of Biomedical Sciences (SSBS), Symbiosis International University (SIU), Symbiosis Knowledge Village, Lavale, Mulshi, Pune, 412115 Maharashtra India.

National Centre for Cell Science (NCCS), NCCS Complex, Pune University Campus, Ganeshkhind, Pune, 411007 Maharashtra India.

出版信息

Syst Synth Biol. 2015 Jun;9(1-2):1-10. doi: 10.1007/s11693-015-9161-2. Epub 2015 Jan 29.

DOI:10.1007/s11693-015-9161-2
PMID:25972984
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4427577/
Abstract

Transforming growth factor-betas (TGF-βs) and their family members that include bone morphogenic proteins and activins have been implicated in the regulation of proliferation, hibernation, quiescence and differentiation of hematopoietic stem cells (HSCs). Increasing evidence suggests that the superfamily of TGF-βs play an integral role in the intercellular cross-talk between the stem cells and their microenvironment as well as within the cells at an intracellular level. Active sites of hematopoiesis, such as fetal liver and bone marrow are known to have abundant presence of TGF-β indicating their importance in the maintenance and regulation of hematopoiesis. One of the striking features of TGF-β superfamily is the variety of effects they evoke, contingent on the developing history of the responding cells. In the present review, we discuss the Smad-dependent and Smad-independent TGF-β signaling pathways in order to understand and underscore their role in the regulation of HSCs.

摘要

转化生长因子-β（TGF-β）及其家族成员，包括骨形态发生蛋白和激活素，已被证实参与造血干细胞（HSC）的增殖、休眠、静止和分化的调控。越来越多的证据表明，TGF-β超家族在干细胞与其微环境之间以及细胞内水平的细胞间相互作用中发挥着不可或缺的作用。已知造血的活跃部位，如胎儿肝脏和骨髓，含有丰富的TGF-β，这表明它们在造血的维持和调控中具有重要意义。TGF-β超家族的一个显著特征是，它们所引发的效应多种多样，这取决于应答细胞的发育历史。在本综述中，我们将讨论Smad依赖和Smad非依赖的TGF-β信号通路，以便理解并强调它们在造血干细胞调控中的作用。