Chiliveru Srikanth, Appari Mahesh, Suravajhala Prashanth
Bioclues.org, Hyderabad, India ; Bioclues.org, Roskilde, Denmark.
Clinic for Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
Syst Synth Biol. 2015 Jun;9(1-2):73-5. doi: 10.1007/s11693-014-9158-2. Epub 2014 Dec 21.
Brucellosis is a zoonotic infection transmitted to humans from infected animals and is one of the widely spread zoonoses. Recently, six species were recognized within the genus Brucella wherein B. melitensis, B. suis and B. abortus are considered virulent for humans. While these species differ phenotypically by their pattern of metabolic activities, there has been an imperative need to understand pathogenesis of Brucella species. It has been foreseen that creating a human vaccine for Brucellosis would entail decreased dose of antibiotics. However the emerging role of Brucella pathogenesis still centers on isolation of the organism and various diagnostic tests thereby leading to varying strategies of treatment cycle. In view of disease heterogeneity, we focus systems and synthetic biology challenges that might improve our understanding the Brucella pathogenesis.
布鲁氏菌病是一种由受感染动物传播给人类的人畜共患感染病，是广泛传播的人畜共患病之一。最近，在布鲁氏菌属中确认了六个物种，其中羊种布鲁氏菌、猪种布鲁氏菌和牛种布鲁氏菌被认为对人类具有致病性。虽然这些物种在代谢活动模式上存在表型差异，但迫切需要了解布鲁氏菌属物种的发病机制。据预测，开发一种用于布鲁氏菌病的人类疫苗将需要减少抗生素剂量。然而，布鲁氏菌发病机制的新作用仍集中在病原体的分离和各种诊断测试上，从而导致不同的治疗周期策略。鉴于疾病的异质性，我们关注可能会增进我们对布鲁氏菌发病机制理解的系统和合成生物学挑战。
