子宫内膜异位症患者子宫内膜基质细胞中粘着斑激酶的表达受卵巢甾体激素调节。
Expression of focal adhesion kinase in endometrial stromal cells of women with endometriosis was adjusted by ovarian steroid hormones.
作者信息
Mu Lin, Ma Yan-Yan
机构信息
Department of Gynecology, The Second Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou, 310009, China.
出版信息
Int J Clin Exp Pathol. 2015 Feb 1;8(2):1810-5. eCollection 2015.
Abstract
The aim of our study is to investigate the effects of ovarian steroid hormones on focal adhesion kinase (FAK) expression in ESCs and whether there is alteration in women with endometriosis. FAK expression was assessed by western blotting analysis. Elevated expression of FAK was seen in the cultured ESCs treated with estrogen (P < 0.05). Expression of FAK protein was not changed in ESCs after treated by progesterone or treated by estrogen and progesterone. The level of up-regulation by estrogen in endometriosis is significantly higher than that from women without endometriosis (P < 0.05). FAK expression in endometrial stromal cells from endometriosis was more sensitive to estrogen, which might contribute to the pathogenesis and progress of endometriosis.
摘要
我们研究的目的是调查卵巢甾体激素对胚胎干细胞中粘着斑激酶（FAK）表达的影响，以及子宫内膜异位症患者是否存在变化。通过蛋白质免疫印迹分析评估FAK表达。在用雌激素处理的培养胚胎干细胞中观察到FAK表达升高（P<0.05）。用孕酮处理或用雌激素和孕酮处理后，胚胎干细胞中FAK蛋白的表达没有变化。子宫内膜异位症患者中雌激素上调水平显著高于非子宫内膜异位症女性（P<0.05）。子宫内膜异位症患者子宫内膜基质细胞中的FAK表达对雌激素更敏感，这可能有助于子宫内膜异位症的发病机制和进展。
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