一名具有47,XXY核型的患者发生急性髓系白血病。
Acute myeloid leukemia in a patient with constitutional 47,XXY karyotype.
作者信息
Jalbut Marla M, Sohani Aliyah R, Dal Cin Paola, Hasserjian Robert P, Moran Jenna A, Brunner Andrew M, Fathi Amir T
机构信息
Tufts University School of Medicine, Boston, MA, United States.
Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
出版信息
Leuk Res Rep. 2015 Apr 22;4(1):28-30. doi: 10.1016/j.lrr.2015.04.001. eCollection 2015.
Klinefelter syndrome (KS), a 47,XXY chromosomal abnormality, has been shown to be associated with a number of malignancies, but has not been linked to acute leukemias to date. We present a case of a 54-year-old male diagnosed with acute myeloid leukemia (AML) with monocytic differentiation, whose cytogenetic and subsequent FISH analyses revealed a constitutional 47,XXY karyotype. We also review and discuss relevant prior literature.
克兰费尔特综合征（KS）是一种47,XXY染色体异常疾病，已被证明与多种恶性肿瘤相关，但迄今为止尚未与急性白血病相关联。我们报告一例54岁男性，诊断为急性髓系白血病（AML）伴单核细胞分化，其细胞遗传学及后续荧光原位杂交（FISH）分析显示存在47,XXY核型。我们还回顾并讨论了相关既往文献。
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