一例具有单核细胞分化及白血病原始细胞噬血细胞现象的急性髓系白血病患者的正常核型。
Normal karyotype in a case of acute myeloid leukemia with monocytic differentiation and hemophagocytosis by leukemic blasts.
作者信息
Salazar Katrina L, Mosse Claudio
机构信息
Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee
Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.
出版信息
Lab Med. 2015 Winter;46(1):64-8. doi: 10.1309/LMUDI1L6PU0MYHSL.
We report the case of a 39-year-old woman with acute myeloid leukemia (AML) with monocytic differentiation showing hemophagocytosis by leukemic blasts. This phenomenon is known to be associated with certain chromosomal changes, including t(8;16), der(8), inv(8), and t(16;21); however, in this case, the patient had a normal female karyotype. To our knowledge, this is the first published case of normal karyotype AML with hemophagocytosis by leukemic blasts.
我们报告了一例39岁患有急性髓系白血病（AML）伴单核细胞分化的女性病例，其白血病原始细胞表现出噬血细胞现象。已知这种现象与某些染色体变化有关，包括t(8;16)、der(8)、inv(8)和t(16;21)；然而，在该病例中，患者的核型为正常女性核型。据我们所知，这是首例发表的具有白血病原始细胞噬血细胞现象的核型正常的AML病例。
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