Gonzalez L P, Czachura J F, Brewer K W
Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, Oklahoma City 73190-3000.
Alcohol. 1989 Nov-Dec;6(6):481-7. doi: 10.1016/0741-8329(89)90056-6.
Ethanol withdrawal symptoms in clinical populations are observed to occur in unique clusters which differ in time of onset relative to the time of withdrawal and in their duration. Since periods of mild symptoms are sometimes observed between these clusters of more severe symptoms, the symptom clusters may reflect separate periods of hyperexcitability during which times different neuronal mechanisms are involved. To investigate this possibility in an animal model of ethanol withdrawal, rats were chronically exposed to ethanol in vapor inhalation chambers. Upon withdrawal from this exposure regimen, the time course of spontaneous seizure activity was observed for a period of 84 hr and compared to sensitivity to seizures elicited by audiogenic stimuli or by the convulsant drug picrotoxin. Spontaneous seizure events were observed to occur in clusters, and these clusters were differentially correlated with periods of increased sensitivity to induced seizure activity. These results further support the suggestion that seizure sensitivity during ethanol withdrawal may indicate the involvement of multiple, independent, neuronal mechanisms.
临床人群中的乙醇戒断症状表现为独特的集群，这些集群在相对于戒断时间的发作时间和持续时间上有所不同。由于在这些较严重症状的集群之间有时会观察到轻度症状期，症状集群可能反映了不同的过度兴奋期，在此期间涉及不同的神经元机制。为了在乙醇戒断的动物模型中研究这种可能性，将大鼠长期置于蒸汽吸入室中接触乙醇。从这种暴露方案中撤药后，观察84小时的自发癫痫活动时间进程，并与对听源性刺激或惊厥药匹鲁卡品诱发的癫痫发作的敏感性进行比较。观察到自发癫痫发作事件以集群形式出现，并且这些集群与对诱发癫痫活动的敏感性增加期有不同程度的相关性。这些结果进一步支持了以下观点，即乙醇戒断期间的癫痫发作敏感性可能表明涉及多种独立的神经元机制。
