Boubaker Mohamed Bader, Haboussi Mohamed, Ganghoffer Jean-François, Aletti Pierre
L.E.M.T.A., Université de Lorraine, C.N.R.S., 54518 Vandoeuvre Cedex, France.
L.S.P.M., U.P.R., C.N.R.S. 3407 Université Paris 13, 99, av. J-B. Clément, 93430 Villetaneuse, France.
J Mech Behav Biomed Mater. 2015 Sep;49:30-42. doi: 10.1016/j.jmbbm.2015.04.016. Epub 2015 Apr 25.
In this paper, a biomechanical approach relying on urodynamic data and mechanical tests is proposed for an accurate prediction of the motion of the pelvic organs in the context of the prostate radiotherapy. As a first step, an experimental protocol is elaborated to characterize the mechanical properties of the bladder and rectum wall tissues; uniaxial tensile tests are performed on porcine substrates. In a second step, the parameters of Ogden-type hyperelastic constitutive models are identified; their relevance in the context of the implementation of a human biomechanical model is verified by means of preliminary Finite Elements (FE) simulations against human urodynamic data. In a third step, the identified constitutive equations are employed for the simulations of the motion and interactions of the pelvic organs due to concomitant changes of the distension volumes of the urinary bladder and rectum. The effectiveness of the developed biomechanical model is demonstrated in investigating the motion of the bladder, rectum and prostate organs; the results in terms of displacements are shown to be in good agreement with measurements inherent to a deceased person, with a relative error close to 6%.
在本文中，提出了一种基于尿动力学数据和力学测试的生物力学方法，用于在前列腺放疗背景下准确预测盆腔器官的运动。第一步，制定了一个实验方案来表征膀胱和直肠壁组织的力学性能；对猪组织样本进行单轴拉伸试验。第二步，确定Ogden型超弹性本构模型的参数；通过针对人体尿动力学数据的初步有限元（FE）模拟，验证了它们在人类生物力学模型实施中的相关性。第三步，将确定的本构方程用于模拟由于膀胱和直肠扩张体积的同时变化而导致的盆腔器官的运动和相互作用。所开发的生物力学模型在研究膀胱、直肠和前列腺器官的运动方面的有效性得到了证明；位移方面的结果显示与一具尸体的测量结果吻合良好，相对误差接近6%。
