Harik S I, Whitney P M, Kalaria R N, Foley J M
Department of Neurology, University Hospitals of Cleveland, Ohio.
Alzheimer Dis Assoc Disord. 1989 Winter;3(4):191-6.
The hexose transporter protein of human erythrocyte membranes was investigated in aging and in demented patients with Alzheimer disease (AD) and Parkinson disease (PD) by assessing the D-glucose-displaceable binding of the ligand cytochalasin-B. We found no alteration in the hexose transporter of erythrocyte membranes in aging or in dementia of AD and PD. These findings indicate that the marked decrease in the density of hexose transporter that we previously reported in the cerebral cortex and brain microvessels in AD do not occur in erythrocyte membranes that have the highest density of the hexose transporter protein.
通过评估配体细胞松弛素B的D-葡萄糖可置换结合，对衰老以及患有阿尔茨海默病（AD）和帕金森病（PD）的痴呆患者的人红细胞膜己糖转运蛋白进行了研究。我们发现在衰老或AD和PD痴呆患者中，红细胞膜己糖转运蛋白没有改变。这些发现表明，我们之前报道的AD患者大脑皮质和脑微血管中己糖转运蛋白密度的显著降低，在己糖转运蛋白密度最高的红细胞膜中并未出现。
