Misra S, Sanyal T, Sarkar D, Bhattacharya P K, Ghosh D K
Department of Immunochemistry, Indian Institute of Chemical Biology, Calcutta.
Biochem Med Metab Biol. 1989 Dec;42(3):171-8. doi: 10.1016/0885-4505(89)90052-2.
TAA, an inhibitor of the enzyme aconitase, inhibits the growth of L. donovani promastigotes. Morphogenic transformation of the amastigote to the promastigote (table; see text) form in vitro was also inhibited by 2 mM TAA. TAA also reduced multiplication of the parasite in macrophage culture. In the hamster model of leishmania, TAA significantly reduced the parasitic burden of liver. In acute toxicity tests with BALB/c mice no deaths were recorded even at a dose level of 2 g/kg body wt/day.
乌头酸酶抑制剂三乙酰丙酮（TAA）可抑制杜氏利什曼原虫前鞭毛体的生长。2 mM的TAA还可抑制体外无鞭毛体向前鞭毛体形态转化（见表；见正文）。TAA还可减少巨噬细胞培养中该寄生虫的增殖。在利什曼原虫的仓鼠模型中，TAA可显著降低肝脏的寄生虫负荷。在对BALB/c小鼠进行的急性毒性试验中，即使剂量达到2 g/kg体重/天，也未记录到死亡情况。
