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高氨血症状态下鸟氨酸转氨甲酰酶缺乏的稀毛小鼠大脑中与血清素和儿茶酚胺相关的物质：两种获取脑提取物方法（断头法和微波辐射法）的比较

Serotonin- and catecholamine-related substances in the brain of ornithine transcarbamylase-deficient Sparse-fur mice in the hyperammonemic state: comparison of two procedures for obtaining brain extract, decapitation and microwave irradiation.

作者信息

Inoue I, Shimizu T, Saheki T, Noda T, Fukuda T

机构信息

Department of Biochemistry, Faculty of Medicine, Kagoshima University, Japan.

出版信息

Biochem Med Metab Biol. 1989 Dec;42(3):232-9. doi: 10.1016/0885-4505(89)90061-3.

DOI:10.1016/0885-4505(89)90061-3
PMID:2597437
Abstract

Increased flux through the 5-HT pathway during hyperammonemia was indicated by a significant positive correlation between Gln concentration and the ratio of 5-HIAA to 5-HT in the brain of spf mice taken after microwave irradiation to prevent postmortem changes in metabolites. There were no significant changes in the catecholamine pathway in the brain during hyperammonemia despite the increases in Try and Phe.

摘要

在对经微波照射的无特定病原体（spf）小鼠脑部进行取样以防止死后代谢物变化后发现，高氨血症期间5-羟色胺（5-HT）途径通量增加，这表现为谷氨酰胺（Gln）浓度与5-羟吲哚乙酸（5-HIAA）与5-HT的比值之间存在显著正相关。尽管色氨酸（Try）和苯丙氨酸（Phe）增加，但高氨血症期间脑部儿茶酚胺途径无显著变化。

相似文献

1
Serotonin- and catecholamine-related substances in the brain of ornithine transcarbamylase-deficient Sparse-fur mice in the hyperammonemic state: comparison of two procedures for obtaining brain extract, decapitation and microwave irradiation.高氨血症状态下鸟氨酸转氨甲酰酶缺乏的稀毛小鼠大脑中与血清素和儿茶酚胺相关的物质：两种获取脑提取物方法（断头法和微波辐射法）的比较
Biochem Med Metab Biol. 1989 Dec;42(3):232-9. doi: 10.1016/0885-4505(89)90061-3.
2
[Brain monoamines and behavior in hyperammonemic sparse-fur mice].[高氨血症稀毛小鼠的脑单胺与行为]
Nihon Yakurigaku Zasshi. 1994 May;103(5):219-29. doi: 10.1254/fpj.103.219.
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Effect of sodium benzoate and sodium phenylacetate on brain serotonin turnover in the ornithine transcarbamylase-deficient sparse-fur mouse.苯甲酸钠和苯乙酸钠对鸟氨酸转氨甲酰酶缺陷型稀毛小鼠脑5-羟色胺代谢率的影响。
Pediatr Res. 1988 Apr;23(4):368-74. doi: 10.1203/00006450-198804000-00006.
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Activities of monoamine oxidase-A and -B are altered in the brains of congenitally hyperammonemic sparse-fur (spf) mice.先天性高氨血症稀毛（spf）小鼠大脑中的单胺氧化酶A和B的活性发生了改变。
Neurosci Lett. 1994 Mar 28;170(1):27-30. doi: 10.1016/0304-3940(94)90230-5.
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Transient hyperammonemia during aging in ornithine transcarbamylase-deficient, sparse-fur mice.鸟氨酸转氨甲酰酶缺乏、毛稀小鼠衰老过程中的短暂高氨血症
Biochem Int. 1985 Nov;11(5):637-43.
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Increase of tryptophan and 5-hydroxyindole acetic acid in the brain of ornithine carbamoyltransferase deficient sparse-fur mice.鸟氨酸氨甲酰基转移酶缺陷型稀毛小鼠大脑中色氨酸和5-羟吲哚乙酸的增加。
Pediatr Res. 1984 Apr;18(4):372-5. doi: 10.1203/00006450-198404000-00014.
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Effects of congenital hyperammonemia on the cerebral and hepatic levels of the intermediates of energy metabolism in spf mice.先天性高氨血症对无特定病原体小鼠能量代谢中间产物的脑和肝水平的影响。
Biochem Biophys Res Commun. 1992 Apr 30;184(2):746-51. doi: 10.1016/0006-291x(92)90653-3.
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Effect of sodium benzoate on cerebral and hepatic energy metabolites in spf mice with congenital hyperammonemia.苯甲酸钠对先天性高氨血症SPF小鼠脑和肝能量代谢物的影响。
Biochem Pharmacol. 1993 Jan 7;45(1):137-46. doi: 10.1016/0006-2952(93)90386-b.
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Ornithine transcarbamylase deficiencies in human males. Kinetic and immunochemical classification.人类男性中的鸟氨酸转氨甲酰酶缺乏症。动力学和免疫化学分类。
Biochim Biophys Acta. 1982 May 21;704(1):100-6. doi: 10.1016/0167-4838(82)90136-4.
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Effect of L-carnitine on cerebral and hepatic energy metabolites in congenitally hyperammonemic sparse-fur mice and its role during benzoate therapy.左旋肉碱对先天性高氨血症稀毛小鼠脑和肝能量代谢产物的影响及其在苯甲酸盐治疗中的作用。
Metabolism. 1993 Aug;42(8):1039-46. doi: 10.1016/0026-0495(93)90020-o.

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