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[相关转运体的改变及其在常见肠道疾病、肝脏疾病、肾脏疾病和糖尿病中的应用意义]

[Alteration of related transporters and its application significance in common intestinal disease, liver disease, renal disease and diabetes].

作者信息

Wang Li, Liu Ke-Xin

出版信息

Yao Xue Xue Bao. 2015 Feb;50(2):127-32.

PMID:25975017
Abstract

Drug transporters are functional membrane proteins located in various tissues, which play vital roles in absorption, distribution and excretion of drugs, especially those located in intestine, liver and kidney. The expression and function of transporters will alter in diseases state, which affects the therapeutic effects of drugs by altering their pharmacokinetics. In this review, we focus on the alterations in related transporters and the effect on the drug therapy in common intestinal diseases, liver diseases, kidney diseases and diabetes mellitus.

摘要

药物转运体是位于各种组织中的功能性膜蛋白，在药物的吸收、分布和排泄中发挥着至关重要的作用，尤其是那些位于肠道、肝脏和肾脏中的转运体。转运体的表达和功能在疾病状态下会发生改变，这通过改变药物的药代动力学来影响药物的治疗效果。在本综述中，我们重点关注常见肠道疾病、肝脏疾病、肾脏疾病和糖尿病中相关转运体的改变及其对药物治疗的影响。

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