[白屈菜提取物对四环素相关性肝炎大鼠肝脏形态功能状态的影响]

[Effect of Hypecoum erectum extract on morphofunctional state of the liver in rats with tetracycline-associated hepatitis].

作者信息

Toropova A A, Nikolaev S M, Razuvaeva Ya G, Fedorov A V, Sambueva Z G, Ubeeva I P

出版信息

Antibiot Khimioter. 2014;59(9-10):25-8.

Abstract

The effect of Hypecoum erectum L. extract on the morphofunctional condition of the liver in rats with experimental tetracycline-associated hepatitis was studied. The experiment included 40 albino rats Wistar. The animals treated with tetracycline hydrochloride (1.0 g/kg body weight) were exposed to the extract in a dose of 50 mg/kg for 5 days. On the 7th day of the experiment the following indices were determined: malonic dialdehyde concentration, catalase activity, the levels of ATP, pyruvate and lactate in the liver homogenate, as well as the blood levels of reduced glutathione. The liver pathomorphological investigation was applied. The H. erectum extract was shown to inhibit lipid peroxidation, to increase the activity of the host endogenous antioxidant system, to normalize the hepatocyte energy provision and to limit the liver degeneration.

摘要

研究了直立紫堇提取物对实验性四环素相关性肝炎大鼠肝脏形态功能状况的影响。实验包括40只Wistar白化大鼠。用盐酸四环素（1.0 g/kg体重）处理的动物以50 mg/kg的剂量给予提取物，持续5天。在实验的第7天，测定以下指标：丙二醛浓度、过氧化氢酶活性、肝匀浆中ATP、丙酮酸和乳酸的水平，以及还原型谷胱甘肽的血中水平。进行了肝脏病理形态学研究。结果表明，直立紫堇提取物可抑制脂质过氧化，提高宿主内源性抗氧化系统的活性，使肝细胞能量供应正常化，并限制肝脏变性。