Grundfest-Broniatowski S, Broniatowski M, Davies C R, Jacobs G B, Tucker H M, Nosé Y
Department of General Surgery, Cleveland Clinic Foundation, OH 44195-5043.
ASAIO Trans. 1989 Jul-Sep;35(3):484-6. doi: 10.1097/00002480-198907000-00101.
Satisfactory rehabilitation of the paralyzed face has yet to be achieved. Ideally, both mobility and symmetry should be restored. In five rabbits, motion signals were picked up from the intact side by miniature strain gauges and channeled by means of an electronic circuit to electrodes placed around nerve pedicles previously implanted into the paralyzed side. An analog current produced in response to muscular contraction (afferent limb) resulted in graded and sustained contraction of the reinnervated side (efferent limb). In six animals, the tension of reinnervated strap muscles could be adjusted by varying the pulse width (0.1-10 msec) of a constant (0.5 mA) current applied to the nerve pedicles. Contraction (strain-gauge compression) of the intact face was followed by reciprocal graded relaxation of the reinnervated straps. Conversely, facial relaxation (elongation) induced graded strap contraction. An agonist-antagonist relationship was, thus, created between the two effectors. This approach may allow the paralyzed face to be electrically reanimated from the intact side in a symmetrical fashion closer to the physiologic state.
面瘫的满意康复尚未实现。理想情况下，面部的活动能力和对称性都应恢复。在五只兔子身上，通过微型应变仪从面部未瘫痪一侧采集运动信号，并通过电子电路将其传输到先前植入瘫痪一侧神经蒂周围的电极上。肌肉收缩（传入支）产生的模拟电流会导致神经再支配一侧（传出支）分级持续收缩。在六只动物身上，通过改变施加在神经蒂上的恒定（0.5毫安）电流的脉冲宽度（0.1 - 10毫秒），可以调节神经再支配的口轮匝肌的张力。未瘫痪面部的收缩（应变仪压缩）之后是神经再支配的口轮匝肌分级的反向松弛。相反，面部松弛（伸长）会引起口轮匝肌分级收缩。因此，在这两个效应器之间建立了一种拮抗关系。这种方法可能使瘫痪的面部从未瘫痪一侧以更接近生理状态的对称方式进行电活动恢复。
