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[单单元活动的长期记录及稳定性评估标准]

[Long-term recording of single unit activity and criteria for estimation of stability].

作者信息

Vasilyeva L N, Badakva A M, Miller N V, Zobova L N, Roschin V Y, Bondar I V

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 2014 Nov-Dec;64(6):693-701.

Abstract

Stable single-unit recording in the brain of vertebrates allows to investigate processes underlying neural plasticity. In applied aspect long-term single-unit recording can be useful for development of invasive brain--computer interface. Here we propose a criterion for identification of neurons that were recorded for more than one day. Based only on the spike forms classification yields ambiguous result. Additional parameters (such as form of interspike interval histogram or certain parameters of that histogram) decreased misclassification probability considerably. Using proposed criterion we were able to identify 82 neurons that were recoded for more than one day. In extreme case activity of one neuron was observed for 94 days.

摘要

在脊椎动物大脑中进行稳定的单神经元记录有助于研究神经可塑性的潜在过程。在应用方面,长期单神经元记录对于侵入性脑机接口的开发可能很有用。在此,我们提出了一种用于识别记录超过一天的神经元的标准。仅基于尖峰形态进行分类会产生模糊的结果。额外的参数(如峰峰间隔直方图的形态或该直方图的某些参数)可显著降低错误分类的概率。使用所提出的标准,我们能够识别出82个记录超过一天的神经元。在极端情况下,观察到一个神经元的活动持续了94天。

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