Zou Jinguo, Ma Yitong, Xie Xiang, Yang Yining, Liu Fen
Department of Cardiology; Xinjiang Key Laboratory of Cardiovascular Disease Research, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
Department of Cardiology; Xinjiang Key Laboratory of Cardiovascular Disease Research, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China; Email:
Zhonghua Liu Xing Bing Xue Za Zhi. 2015 Apr;36(4):393-8.
To assess the association between human CYP1A1 gene polymorphisms and coronary artery disease (CAD) among the Uygur population of China.
Genotypes of CYP1A1 single nucleotide polymorphisms (SNPs: rs4886605, rs12441817, rs4646422 and rs1048943) were detected by real-time PCR in 293 CAD patients and 408 controls.
Among the Uygur group, distribution of genotypes and allele of rs4886605 were both significantly different between CAD and the controls (all P < 0.05). The dominant model (CC vs. CT+TT) of rs4886605 was significantly lower among CAD patients than in controls. Significant differences were retained after the adjustment was made in all the participants (OR = 0.368, 95% CI: 0.185-0.530, P = 0.018) and in men (OR = 0.350, 95% CI: 0.235-0.568, P = 0.015). Distributions of genotypes and allele of rs12441817 were both significantly different between CAD and the controls (all P < 0.05). The dominant model (TT vs. CT+CC) of rs12441817 was significantly lower among patients CAD than in controls. Significant difference were retained after the adjustment was made, in total participants (OR = 0.253, 95% CI: 0.231-0.546, P = 0.016) and in men (OR = 0.241, 95% CI: 0.132-0.478, P = 0.002).
Both rs4886605 and rs12441817 SNPs of the CYP1A1 gene were associated with CAD in the Uygur population of China.
评估中国维吾尔族人群中人类细胞色素P450 1A1（CYP1A1）基因多态性与冠状动脉疾病（CAD）之间的关联。
采用实时荧光定量聚合酶链反应（PCR）检测293例CAD患者和408例对照者CYP1A1单核苷酸多态性（SNPs：rs4886605、rs12441817、rs4646422和rs1048943）的基因型。
在维吾尔族人群中，CAD患者与对照者之间rs4886605的基因型和等位基因分布均存在显著差异（均P<0.05）。rs4886605的显性模型（CC与CT+TT）在CAD患者中显著低于对照者。在所有参与者（比值比[OR]=0.368，95%可信区间[CI]：0.185-0.530，P=0.018）和男性（OR=0.350，95%CI：0.235-0.568，P=0.015）中进行校正后，差异仍然显著。CAD患者与对照者之间rs12441817的基因型和等位基因分布均存在显著差异（均P<0.05）。rs12441817的显性模型（TT与CT+CC）在CAD患者中显著低于对照者。在所有参与者（OR=0.253，95%CI：0.231-0.546，P=0.016）和男性（OR=0.241，95%CI：0.132-0.478，P=0.002）中进行校正后，差异仍然显著。
在中国维吾尔族人群中，CYP1A1基因的rs4886605和rs12441817这两个SNPs均与CAD相关。
