在猪模型体外循环期间，使用铟 - 111标记的血小板对中空纤维膜式氧合器和动脉滤器中的血小板损失进行定量分析。
Quantitation of platelet loss with indium-111 labeled platelets in a hollow-fiber membrane oxygenator and arterial filter during extracorporeal circulation in a pig model.
作者信息
Palatianos G M, Dewanjee M K, Robinson R P, Novak S, Dewanjee P K, Kapadvanjwala M, Hsu L C, Sfakianakis G N, Kaiser G A
机构信息
Divisions of Thoracic and Cardiovascular Surgery, University of Miami School of Medicine, FL 33101.
出版信息
ASAIO Trans. 1989 Jul-Sep;35(3):667-70. doi: 10.1097/00002480-198907000-00162.
Platelet consumption in a hollow-fiber membrane oxygenator (HFMO) and arterial filter (AF) during cardiopulmonary bypass (CPB) was quantified in five pigs using Indium-111 labeled autologous platelets. Platelet labeling was performed 20-24 hours before CPB. After general endotracheal anesthesia, the pigs were systemically heparinized and were placed on CPB via a median sternotomy. After 3 hours of CPB, radioactivity was quantified with a gamma camera and an ionization chamber. The percent of injected dose (mean +/- SD) was 0.79 +/- 0.45 in the HFMO, 2.52 +/- 0.93 in AF, 4.3 +/- 1.2 in blood loss during CPB. Platelet consumption in HFMO during CPB was lower than in bubble oxygenators (19%) or silicone membrane oxygenators (12%) as observed in previous studies.
使用铟 - 111标记的自体血小板，对5头猪在体外循环（CPB）期间中空纤维膜氧合器（HFMO）和动脉滤器（AF）中的血小板消耗情况进行了定量分析。血小板标记在CPB前20 - 24小时进行。在全身气管内麻醉后，猪全身肝素化，并通过正中胸骨切开术置于CPB上。CPB 3小时后，用γ相机和电离室对放射性进行定量分析。注入剂量的百分比（平均值±标准差）在HFMO中为0.79±0.45，在AF中为2.52±0.93，在CPB期间失血中为4.3±1.2。如先前研究所观察到的，CPB期间HFMO中的血小板消耗低于鼓泡氧合器（19%）或硅膜氧合器（12%）。
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