Palatianos G M, Dewanjee M K, Robinson R P, Novak S, Dewanjee P K, Kapadvanjwala M, Hsu L C, Sfakianakis G N, Kaiser G A
Divisions of Thoracic and Cardiovascular Surgery, University of Miami School of Medicine, FL 33101.
ASAIO Trans. 1989 Jul-Sep;35(3):667-70. doi: 10.1097/00002480-198907000-00162.
Platelet consumption in a hollow-fiber membrane oxygenator (HFMO) and arterial filter (AF) during cardiopulmonary bypass (CPB) was quantified in five pigs using Indium-111 labeled autologous platelets. Platelet labeling was performed 20-24 hours before CPB. After general endotracheal anesthesia, the pigs were systemically heparinized and were placed on CPB via a median sternotomy. After 3 hours of CPB, radioactivity was quantified with a gamma camera and an ionization chamber. The percent of injected dose (mean +/- SD) was 0.79 +/- 0.45 in the HFMO, 2.52 +/- 0.93 in AF, 4.3 +/- 1.2 in blood loss during CPB. Platelet consumption in HFMO during CPB was lower than in bubble oxygenators (19%) or silicone membrane oxygenators (12%) as observed in previous studies.
使用铟 - 111标记的自体血小板，对5头猪在体外循环（CPB）期间中空纤维膜氧合器（HFMO）和动脉滤器（AF）中的血小板消耗情况进行了定量分析。血小板标记在CPB前20 - 24小时进行。在全身气管内麻醉后，猪全身肝素化，并通过正中胸骨切开术置于CPB上。CPB 3小时后，用γ相机和电离室对放射性进行定量分析。注入剂量的百分比（平均值±标准差）在HFMO中为0.79±0.45，在AF中为2.52±0.93，在CPB期间失血中为4.3±1.2。如先前研究所观察到的，CPB期间HFMO中的血小板消耗低于鼓泡氧合器（19%）或硅膜氧合器（12%）。
