General Surgery Unit, Department of Oncology Transplantation and New Technologies, University of Pisa, Via Paradisa 2, Pisa 56124, Italy; EndoCAS (Centre for Computer-Assisted Surgery), University of Pisa, Pisa, Italy.
General Surgery Unit, Department of Oncology Transplantation and New Technologies, University of Pisa, Via Paradisa 2, Pisa 56124, Italy.
Int J Infect Dis. 2015 Jul;36:4-5. doi: 10.1016/j.ijid.2015.05.001. Epub 2015 May 11.
A 68-year-old male underwent a right hepatectomy, resection of the biliary convergence, and a left hepatic jejunostomy for a Klatskin tumour. The postoperative course was complicated by biliary abscesses with relapsing bloodstream infections due to Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae (KPC-Kp). A 2-week course of combination antibiotic therapy failed to provide source control and the bacteraemia relapsed. Success was obtained with a regimen of tigecycline 100mg daily for 2 months, followed by tigecycline 50mg daily for 6 months, then 50mg every 48h for 3 months. No side effects were reported.
一位 68 岁男性因 Klatskin 肿瘤接受了右肝切除术、胆管汇合部切除术和左肝空肠吻合术。术后发生胆管脓肿，伴有反复发作的血流感染，病原体为产碳青霉烯酶肺炎克雷伯菌（KPC）的肺炎克雷伯菌（KPC-Kp）。2 周的联合抗生素治疗未能控制感染源，菌血症再次复发。使用替加环素 100mg 每日治疗 2 个月，然后替加环素 50mg 每日治疗 6 个月，之后每 48 小时 50mg 治疗 3 个月，获得成功。未报告任何副作用。
