Liu Xiaoling, Yang Mudan, Gao Jun, Zhang Suzhen, Xi Yanfeng
the Second Department of Digestive Diseases, Shanxi Tumor Hospital, Taiyuan 030013, China.
Email:
Zhonghua Zhong Liu Za Zhi. 2015 Mar;37(3):231-4.
To analyze the clinicopathologic features and prognosis of α-fetoprotein (AFP)-producing gastric cancers (AFPGC).
Fifty-one serum AFP-positive patients with positive immunohistochemical staining of AFP in the primary lesions (study group) and sixty-five gastric cancer cases with normal AFP level (control group) treated in our department from January 2005 to December 2007 were included in this study. Their clinicopathologic features and follow-up data were statistically analyzed.
Compared with the control group, the study group had a higher incidence of poorly differentiated adenocarcinoma (P=0.021) and liver metastasis (P=0.001) than that in the control group.The TNM stages in the study group were significantly higher than those in the control group (P=0.001). The 1-, 2-, and 5-year survival rates of the study group were 62.7%, 27.5% and 4.7%, respectively, and the median survival was 16 months, significantly lower than the 84.6%, 55.4%, 16.5%, and 30 months of the control group (P<0.001 for all). The serum AFP levels in the study group ranged from 58.63 µg/L to 12 100.00 µg/L, and could be classified into two groups:27 cases <500 µg/L, and 24 cases ≥500 µg/L. There was no significant difference of the immunohistochemical staining results between the two subgroups (P=0.912).
AFPGC is a special type of gastric cancer with high degree of malignancy and poor prognosis. Monitoring of serum AFP level can earlier detect the progression of disease and give corresponding treatment.
分析产甲胎蛋白（AFP）的胃癌（AFPGC）的临床病理特征及预后。
纳入2005年1月至2007年12月在我科治疗的51例血清AFP阳性且原发灶免疫组化染色AFP阳性的患者（研究组）和65例AFP水平正常的胃癌病例（对照组）。对其临床病理特征及随访数据进行统计学分析。
与对照组相比，研究组低分化腺癌的发生率（P=0.021）和肝转移率（P=0.001）均高于对照组。研究组的TNM分期显著高于对照组（P=0.001）。研究组的1年、2年和5年生存率分别为62.7%、27.5%和4.7%，中位生存期为16个月，显著低于对照组的84.6%、55.4%、16.5%和30个月（所有P<0.001）。研究组血清AFP水平为58.63μg/L至12100.00μg/L，可分为两组：27例<500μg/L，24例≥500μg/L。两个亚组的免疫组化染色结果无显著差异（P=0.912）。
AFPGC是一种特殊类型的胃癌，恶性程度高，预后差。监测血清AFP水平可早期发现疾病进展并给予相应治疗。
