Teipel Stefan J, Grothe Michel J, Wittfeld Katharina, Hoffmann Wolfgang, Hegenscheid Katrin, Völzke Henry, Homuth Georg, Grabe Hans J
Department of Psychosomatic Medicine, University of Rostock, Rostock, Germany; DZNE, German Center for Neurodegenerative Diseases, Rostock/Greifswald, Rostock, Germany.
DZNE, German Center for Neurodegenerative Diseases, Rostock/Greifswald, Rostock, Germany.
Neurobiol Aging. 2015 Jun;36(6):2060-7. doi: 10.1016/j.neurobiolaging.2014.12.031. Epub 2015 Jan 6.
The neuropeptide neurokinin 3 (NK3) and its receptor modulate cholinergic activity of the basal forebrain (BF) and are implicated in learning and memory. In Alzheimer's disease, the rs2765 single-nucleotide polymorphism (SNP) of the NK3 receptor-coding gene TACR3 was correlated with the right hippocampus volume. Here, we studied the association of the rs2765 SNP with magnetic resonance imaging-based volumes of the BF and hippocampus in a population-based sample of 1967 participants between 21 and 90 years of age. The rs2765 SNP was significantly associated with the most anterior BF volume corresponding to the medial septum/diagonal band, and with a significantly steeper age-related volume decline. The rs2765 SNP was not associated with other BF subvolumes or hippocampus volumes. Apolipoprotein E ε4 showed no correlation with any brain volume or global cognition. Our findings in a large population-based sample suggest an association of an NK3 receptor SNP with age-related decline of rostral cholinergic BF volume.
神经肽神经激肽3（NK3）及其受体调节基底前脑（BF）的胆碱能活性，并与学习和记忆有关。在阿尔茨海默病中，NK3受体编码基因TACR3的rs2765单核苷酸多态性（SNP）与右侧海马体积相关。在此，我们在一个基于人群的样本中研究了rs2765 SNP与基于磁共振成像的BF和海马体积之间的关联，该样本包括1967名年龄在21至90岁之间的参与者。rs2765 SNP与对应于内侧隔/斜角带的最前部BF体积显著相关，并且与年龄相关的体积下降显著更陡峭有关。rs2765 SNP与其他BF亚体积或海马体积无关。载脂蛋白E ε4与任何脑体积或整体认知均无相关性。我们在一个基于人群的大样本中的研究结果表明，NK3受体SNP与喙侧胆碱能BF体积的年龄相关下降有关。
