Li Jun, Yu Li, Yang Junhui, Long Ding, Zhang Yuanchao, Bu Xiaofen
Intensive Care Unit, Wuhan Central Hospital, Wuhan 430014, China.
Intensive Care Unit, Wuhan Central Hospital, Wuhan 430014, China; Email:
Zhonghua Yi Xue Za Zhi. 2015 Mar 10;95(9):659-62.
To explore the incidence and species distribution of catheter-related bloodstream infection (CRBSI) in intensive care unit (ICU) at our hospital and analyze the risk factors for CRBSI.
Hospitalized patients microbiologically diagnosed as CRBSI were recruited from January 2012 to June 2013. And the clinical data were collected retrospectively and analyzed by software IBM SPSS 19.0.
Among 67 patients diagnosed as nosocomial CRBSI, 24 cases (35.8%) died while 43 survived. And a total of 81 strains were detected, including 42 Gram-positive (G⁺) bacteria (51.9%), 36 Gram-negative (G⁻) bacteria (44.4%) and 3 fungi (3.7%).The predominant pathogenic G⁺ and G⁻ bacteria were Staphylococcus epidermidis and Acinetobacter baumannii respectively. With multiple Logistic regressions, age ≥ 65 years, higher acute physiology & chronic health evaluation II (APACHE II) score and polymicrobial CRBSI were independent predictors of worse outcomes.
The recent prevalent pathogens of CRBSI in ICU are S.epidermidis and A.baumannii. Advanced age, disease severity and polymicrobial CRBSI are significant independent risk factor of mortality for CRBSI patients in ICU.
探讨我院重症监护病房（ICU）导管相关血流感染（CRBSI）的发生率及菌种分布，并分析CRBSI的危险因素。
选取2012年1月至2013年6月间微生物学诊断为CRBSI的住院患者。回顾性收集临床资料，并用IBM SPSS 19.0软件进行分析。
67例医院获得性CRBSI患者中，24例（35.8%）死亡，43例存活。共检测到81株菌株，其中革兰阳性（G⁺）菌42株（51.9%），革兰阴性（G⁻）菌36株（44.4%），真菌3株（3.7%）。主要致病G⁺菌和G⁻菌分别为表皮葡萄球菌和鲍曼不动杆菌。多因素Logistic回归分析显示，年龄≥65岁、急性生理与慢性健康状况评分系统II（APACHE II）评分较高以及多重微生物CRBSI是预后较差的独立预测因素。
ICU近期CRBSI的主要病原菌是表皮葡萄球菌和鲍曼不动杆菌。高龄、疾病严重程度和多重微生物CRBSI是ICU中CRBSI患者死亡的重要独立危险因素。
