Kiem Sungmin, Ryu Sung-Mun, Lee Yun-Mi, Schentag Jerome J, Kim Yang-Wook, Kim Hyeon-Kuk, Jang Hang-Jae, Joo Yong-Don, Jin Kyubok, Shin Jae-Gook, Ghim Jong-Lyul
a Department of Internal Medicine , Inje University Haeundae Paik Hospital , Busan , Republic of Korea.
b Department of Pharmacology, PharmacoGenomics Research Center , Inje University College of Medicine , Busan , Republic of Korea.
J Chemother. 2016 Aug;28(4):308-13. doi: 10.1179/1973947815Y.0000000033.
Levofloxacin (LVFX) has different effects depending on the area under the concentration-time curve (AUC)/minimum inhibitory concentration (MIC) ratio. While AUC can be expressed as dose/clearance (CL), we measured serial concentrations of LVFX in Koreans and tried to set a Korean-specific equation, estimating the CL of the antibiotic. In total, 38 patients, aged 18-87 years, received once daily intravenous LVFX doses of 500 mg or 250 mg, depending on their renal function. Four plasma samples were obtained according to a D optimal sampling design. The population pharmacokinetic (PK) parameters of LVFX were estimated using non-linear mixed-effect modeling (NONMEM, ver. 7.2). The CL of LVFX was dependent on creatinine clearance (CLCR) as a covariate. The mean population PK parameters of LVFX in Koreans were as follows: CL (l/hour) = 6.19 × (CLCR/75)(1.32). The CL of LVFX in Koreans is expected to be lower than that in Western people.
左氧氟沙星（LVFX）根据浓度-时间曲线下面积（AUC）/最低抑菌浓度（MIC）比值具有不同的效应。虽然AUC可以表示为剂量/清除率（CL），但我们测定了韩国人左氧氟沙星的系列浓度，并试图建立一个韩国人特异性方程，以估算该抗生素的清除率。共有38例年龄在18至87岁之间的患者，根据其肾功能，每日静脉注射一次500mg或250mg的左氧氟沙星。根据D最优抽样设计采集了4份血浆样本。使用非线性混合效应模型（NONMEM，版本7.2）估算左氧氟沙星的群体药代动力学（PK）参数。左氧氟沙星的清除率依赖于作为协变量的肌酐清除率（CLCR）。韩国人左氧氟沙星的平均群体PK参数如下：CL（升/小时）=6.19×（CLCR/75）（1.32）。预计韩国人左氧氟沙星的清除率低于西方人。
