Tuokkola Terhi, Koikkalainen Juha, Parkkola Riitta, Karrasch Mira, Lötjönen Jyrki, Rinne Juha O
Turku PET Centre, Turku University Hospital, Finland University of Turku, Turku, Finland
VTT Technical Research Centre of Finland, Tampere, Finland.
Acta Radiol. 2016 Mar;57(3):348-55. doi: 10.1177/0284185115584656. Epub 2015 May 14.
Atrophy of the medial temporal lobe (MTL) is the main structural magnetic resonance imaging (MRI) finding in the brain of patients with Alzheimer's disease (AD). However, evaluating the degree of atrophy is still demanding.
The visual rating method (VRM) was compared with multi-template tensor-based morphometry (TBM), in terms of its efficacy in diagnosing of mild cognitive impairment (MCI) and AD.
Forty-seven patients with MCI, 80 patients with AD and 84 controls were studied.
TBM seems to be more sensitive than VRM at the early stage of dementia in the areas of MTL and ventricles. The methods were equally good in distinguishing controls and the MCI group from the AD group. At the frontal areas TBM was better than VRM in all comparisons.
A user-friendly VRM is still useful for the clinical evaluation of MCI patients, but multi-template TBM is more sensitive for diagnosing the early stages of dementia. However, TBM is currently too demanding to use for daily clinical work.
内侧颞叶（MTL）萎缩是阿尔茨海默病（AD）患者大脑主要的结构磁共振成像（MRI）表现。然而，评估萎缩程度仍然具有挑战性。
比较视觉评分法（VRM）与多模板基于张量的形态测量法（TBM）在诊断轻度认知障碍（MCI）和AD方面的有效性。
对47例MCI患者、80例AD患者和84例对照者进行了研究。
在痴呆早期，MTL和脑室区域TBM似乎比VRM更敏感。在区分对照组和MCI组与AD组方面，两种方法效果相当。在所有比较中，额叶区域TBM比VRM更好。
用户友好的VRM对MCI患者的临床评估仍然有用，但多模板TBM对痴呆早期诊断更敏感。然而，目前TBM用于日常临床工作要求过高。
