实验性头颈癌中重复[(18)F]EF5 PET/CT扫描及肿瘤生长率的评估
Evaluation of repeated [(18)F]EF5 PET/CT scans and tumor growth rate in experimental head and neck carcinomas.
作者信息
Silvoniemi Antti, Silén Jonna, Forsback Sarita, Löyttyniemi Eliisa, Schrey Aleksi R, Solin Olof, Grénman Reidar, Minn Heikki, Grönroos Tove J
机构信息
Turku PET Centre, Medicity Research Laboratory, University of Turku, Tykistökatu 6A, Turku, FI-20520, Finland ; Department of Otorhinolaryngology - Head and Neck Surgery, Turku University Hospital, Turku, FI-20521, Finland.
Turku PET Centre, Medicity Research Laboratory, University of Turku, Tykistökatu 6A, Turku, FI-20520, Finland.
出版信息
EJNMMI Res. 2014 Dec 16;4:65. doi: 10.1186/s13550-014-0065-z. eCollection 2014.
BACKGROUND
Tumor hypoxia is linked to invasion and metastasis but whether this associates with tumor growth rate is not well understood. We aimed to study the relationship between hypoxia evaluated with the positron emission tomography (PET) tracer [(18)F]EF5 and tumor growth. Our second goal was to assess the variability in the uptake of [(18)F]EF5 in tumor between two scans.
METHODS
Four human head and neck squamous cell carcinoma (UT-SCC) cell lines were xenografted in flank or neck of nude mice, and tumor size was closely monitored over the study period. The tumors were clearly visible when the first [(18)F]EF5 scan was acquired. After an exponential growth phase, the tumors were imaged again with [(18)F]EF5 and also with (18)F-fluorodeoxyglucose ([(18)F]FDG).
RESULTS
There was a clear correlation between the percentage of tumor growth rate per day and the [(18)F]EF5 uptake in the latter scan (r = 0.766, p = 0.01). The uptake of [(18)F]EF5 in the first scan and the uptake of [(18)F]FDG did not significantly correlate with the tumor growth rate. We also observed considerable variations in the uptake of [(18)F]EF5 between the two scans.
CONCLUSIONS
The uptake of [(18)F]EF5 in the late phase of exponential tumor growth is associated with the tumor growth rate in mice bearing HNC xenografts.
背景
肿瘤缺氧与侵袭和转移有关，但这种情况是否与肿瘤生长速率相关尚不清楚。我们旨在研究用正电子发射断层扫描（PET）示踪剂[(18)F]EF5评估的缺氧与肿瘤生长之间的关系。我们的第二个目标是评估两次扫描之间肿瘤中[(18)F]EF5摄取的变异性。
方法
将四种人头颈部鳞状细胞癌（UT-SCC）细胞系接种到裸鼠的胁腹或颈部，在研究期间密切监测肿瘤大小。在进行首次[(18)F]EF5扫描时，肿瘤清晰可见。在指数生长期后，再次用[(18)F]EF5以及(18)F-氟脱氧葡萄糖([(18)F]FDG)对肿瘤进行成像。
结果
每日肿瘤生长速率百分比与后一次扫描中[(18)F]EF5摄取之间存在明显相关性（r = 0.766，p = 0.01）。第一次扫描中[(18)F]EF5的摄取以及[(18)F]FDG的摄取与肿瘤生长速率无显著相关性。我们还观察到两次扫描之间[(18)F]EF5摄取存在相当大的差异。
结论
在荷人鼻咽癌异种移植瘤小鼠中，肿瘤指数生长后期[(18)F]EF5的摄取与肿瘤生长速率相关。
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