Dai Jian, Li Qianqian, Liu Wenya, Lin Shudong, Hao Yaoyao, Zhang Chao, Shuai Xintao
School of Engineering, Sun Yat-sen University, Guangzhou 510006, P. R. China.
Chem Commun (Camb). 2015 Jun 14;51(47):9682-5. doi: 10.1039/c5cc02556g.
Novel gold-shell nanoparticles (pH-GSNPs) are designed for the first time, which exhibit drug leakage-free behavior in a physiological environment, while achieving rapid drug release and remarkable aggregation for the nanogold interlayer of pH-GSNPs to shift their absorption to far-red and NIR as a photothermal agent in the intracellular microenvironment.
新型金壳纳米颗粒（pH-GSNPs）首次被设计出来，它在生理环境中表现出无药物泄漏行为，同时实现快速药物释放，并且pH-GSNPs的纳米金夹层会显著聚集，使其在细胞内微环境中作为光热剂时吸收峰移至远红光和近红外光区域。
